NOP10 Antibody

Code CSB-PA873610LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: NOP10 antibody at 4µg/ml
    Lane 1: Jurkat whole cell lysate
    Lane 2: Caco-2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 8 kDa
    Observed band size: 8 kDa

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA873610LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA873610LA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) NOP10 Polyclonal antibody
Uniprot No. Q9NPE3
Target Names NOP10
Alternative Names DKCB1 antibody; H/ACA ribonucleoprotein complex subunit 3 antibody; homolog of yeast Nop10p antibody; MGC70651 antibody; NOLA3 antibody; NOP10 antibody; NOP10 ribonucleoprotein homolog (yeast) antibody; NOP10_HUMAN antibody; NOP10P antibody; Nucleolar protein 10 antibody; Nucleolar protein family A member 3 antibody; nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs) antibody; snoRNP protein NOP10 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human H/ACA ribonucleoprotein complex subunit 3 protein (1-64AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Gene References into Functions
  1. Indian aplastic anemia patients did not have NOP10 mutations. PMID: 25906515
  2. Effects of dyskeratosis congenita mutations in NOP10 on assembly of H/ACA pre-RNPs PMID: 20008900
  3. NOP10 has a role in the telomerase complex and telomere maintenance, and in autosomal recessive dyskeratosis congenita PMID: 17507419
Involvement in disease Dyskeratosis congenita, autosomal recessive, 1 (DKCB1)
Subcellular Location Nucleus, nucleolus, Nucleus, Cajal body
Protein Families NOP10 family
Database Links

HGNC: 14378

OMIM: 224230

KEGG: hsa:55505

STRING: 9606.ENSP00000332198

UniGene: Hs.14317

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