NPL Antibody

Datasheet

Code	CSB-PA015994GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q9BXD5

Target Names

NPL

Alternative Names

0610033B02Rik antibody; C112 antibody; C1orf13 antibody; Dihydrodipicolinate synthase antibody; Dihydrodipicolinate synthetase homolog 1 antibody; MGC149582 antibody; MGC61869 antibody; N-acetylneuraminate lyase antibody; N-acetylneuraminate pyruvate-lyase antibody; N-acetylneuraminic acid aldolase antibody; NAL antibody; NALase antibody; NPL antibody; NPL_HUMAN antibody; NPL1 antibody; RP11-249O6.1 antibody; Sialate lyase antibody; Sialate-pyruvate lyase antibody; Sialic acid aldolase antibody; Sialic acid lyase antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human NPL

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Experiments show the true substrate is aceneuramate (linearized Neu5Ac).

Gene References into Functions

an NPL splice variant is mainly expressed in human liver, kidney and peripheral blood leukocytes PMID: 16147865
3D structure model of N-acetylneuraminate lyase from human (hNAL, EC 4.1.3.3) was created and refined PMID: 19057931

Subcellular Location

Cytoplasm.

Protein Families

DapA family, NanA subfamily

Tissue Specificity

Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.

Database Links

HGNC: 16781

OMIM: 611412

KEGG: hsa:80896

STRING: 9606.ENSP00000258317

UniGene: Hs.496969

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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