Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Experiments show the true substrate is aceneuramate (linearized Neu5Ac).
Gene References into Functions
an NPL splice variant is mainly expressed in human liver, kidney and peripheral blood leukocytes PMID: 16147865
3D structure model of N-acetylneuraminate lyase from human (hNAL, EC 4.1.3.3) was created and refined PMID: 19057931
Subcellular Location
Cytoplasm.
Protein Families
DapA family, NanA subfamily
Tissue Specificity
Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.