NPRL2 Antibody

Code CSB-PA062668
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA062668(NPRL2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA062668(NPRL2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
NPRL2
Alternative Names
2810446G01Rik antibody; G21 protein antibody; Gene 21 protein antibody; Homologous to yeast nitrogen permease (candidate tumor suppressor) antibody; Homologous to yeast nitrogen permease antibody; Nitrogen permease regulator 2-like protein antibody; Nitrogen permease regulator-like 2 (S. cerevisiae) antibody; NPR 2L antibody; NPR L2 antibody; NPR like 2 antibody; NPR2 antibody; NPR2 like antibody; NPR2-like protein antibody; NPR2L antibody; NPRL 2 antibody; NPRL2 antibody; NPRL2_HUMAN antibody; Tumor suppressor candidate 4 antibody; TUSC 4 antibody; TUSC 4 protein antibody; TUSC4 antibody; TUSC4 protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide of Human NPRL2
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.; Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.
Gene References into Functions
  1. NPRL2 overexpression enhances sensitivity to CPT-11 treatment in colon cancer cells. PMID: 29519997
  2. This study demonstrated that NPRL2 mutation in familial focal epilepsies and focal cortical dysplasia. PMID: 27173016
  3. Data confirmed NPRL2 was downregulated in gliomas. More importantly, NPRL2 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a tumor suppressor. PMID: 26455908
  4. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor. PMID: 26582740
  5. NPRL2 mutations are significant cause of focal epilepsy. PMID: 26505888
  6. NPRL2 acts as a functional tumor suppressor in colorectal cancer cell lines. PMID: 26044952
  7. NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells. PMID: 25777765
  8. Decreased expression of NPRL2 is associated with renal cancer. PMID: 24789683
  9. NPRL2 mRNA blood levels could be a potentially useful marker for the detection of early stage adenomas and colorectal cancers. PMID: 24521741
  10. Results provide a set of genetic and biologic proofs that TUSC4 functions as a bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer. PMID: 25480944
  11. NPRL2 expression is negatively related with the survival of osteosarcoma patients, indicating its value as a prognosis factor of osteosarcoma. PMID: 23321467
  12. Lower NPRL2 expression was observed significantly more frequently in poorly differentiated tumor samples than in highly or moderately differentiated colon tumors. PMID: 23079973
  13. Data indicate that Npr2, a homolog of human NPRL2, is a phosphorylation-dependent target of the SCF(Grr1) E3 ubiquitin ligase that plays a role in cell growth on some nitrogen sources. PMID: 20154027
  14. NPRL2 is a multiple tumor suppressor gene. PMID: 15374952
  15. Expression of NPRL2 was significantly and reciprocally correlated to cisplatin sensitivity. PMID: 17018626
  16. TUSC4/NPRL2, a novel PDK1-interacting protein, plays a role in regulating the Src/PDK1 signaling pathway and cell sensitivity to multiple cancer chemotherapeutic drugs. PMID: 18616680
  17. Our results suggest that NPRL2 mRNA expression has prognostic significance for the survival of patients with HCC. PMID: 19274676

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Involvement in disease
Epilepsy, familial focal, with variable foci 2 (FFEVF2)
Subcellular Location
Lysosome membrane.
Protein Families
NPR2 family
Tissue Specificity
Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes. Expressed in most lung cancer
Database Links

HGNC: 24969

OMIM: 607072

KEGG: hsa:10641

STRING: 9606.ENSP00000232501

UniGene: Hs.437083

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