NRCAM Antibody

Code CSB-PA016074LA01HU
Size US$166
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Image
  • IHC image of CSB-PA016074LA01HU diluted at 1:200 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA016074LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of 293 cells with CSB-PA016074LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NRCAM Polyclonal antibody
Uniprot No.
Target Names
NRCAM
Alternative Names
Bravo antibody; hBravo antibody; Neuronal cell adhesion molecule antibody; Neuronal surface protein Bravo antibody; Ng CAM related antibody; Ng-CAM-related antibody; NgCAM related cell adhesion molecule antibody; NgCAM-related cell adhesion molecule antibody; Nr CAM antibody; Nr-CAM antibody; Nrcam antibody; NRCAM_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Neuronal cell adhesion molecule protein (1194-1299AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NRCAM Antibody (Product code: CSB-PA016074LA01HU) is Non-conjugated. For NRCAM Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA016074LB01HU NRCAM Antibody, HRP conjugated ELISA
FITC CSB-PA016074LC01HU NRCAM Antibody, FITC conjugated
Biotin CSB-PA016074LD01HU NRCAM Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.
Gene References into Functions
  1. Increased gene expression of NrCAM may be used as a potential diagnostic marker for papillary thyroid cancer. PMID: 27732334
  2. A high level of Nr-CAM expression is associated with favorable tumor phenotype and reduced risk of prostate cancer recurrence. PMID: 23338556
  3. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM PMID: 21876539
  4. mechanisms of NrCAM participation in development and how these might be perturbed in disorders are reviewed. [review] PMID: 22182708
  5. Nr-CAM protein expression is upregulated in colorectal cancer tissues; Nr-CAM overexpression is an independent marker of poor prognosis among advanced CRC patients, and a possible predictive marker for non-beneficence to 5-fluorouracil-based chemotherapy PMID: 21718388
  6. Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM PMID: 11866539
  7. induction of Nr-CAM transcription plays a role in melanoma and colon cancer tumorigenesis PMID: 12183361
  8. NrCAM is overexpressed in human papillary thyroid carcinoma at the mRNA and protein levels, whatever the tumour stage. PMID: 17667921
  9. Distinct cytokeratin 7, cytokeratin 19, & neuronal cell adhesion molecule staining patterns are seen in hepatic adenoma & focal nodular hyperplasia possibly suggest activation of different subsets of hepatic progenitor/stem cell. PMID: 18602664
  10. our results indicated that the NRCAM gene is one of the strong candidate genes for autism PMID: 18664314

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Secreted.
Protein Families
Immunoglobulin superfamily, L1/neurofascin/NgCAM family
Tissue Specificity
Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
Database Links

HGNC: 7994

OMIM: 601581

KEGG: hsa:4897

STRING: 9606.ENSP00000368314

UniGene: Hs.21422

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