Nsf Antibody

^{Rare Species}

Datasheet

Code	CSB-PA15457A0Rb
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Rattus norvegicus (Rat) Nsf Polyclonal antibody

Uniprot No.

Q9QUL6

Target Names

Nsf

Alternative Names

Nsf antibody; Erg1 antibody; Vesicle-fusing ATPase antibody; EC 3.6.4.6 antibody; N-ethylmaleimide-sensitive fusion protein antibody; NEM-sensitive fusion protein antibody; Vesicular-fusion protein NSF antibody

Raised in

Rabbit

Species Reactivity

Rat

Immunogen

Recombinant Rat Vesicle-fusing ATPase protein (7-209AA)

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

The Nsf Antibody (Product code: CSB-PA15457A0Rb) is Non-conjugated. For Nsf Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA15457B0Rb	Nsf Antibody, HRP conjugated	ELISA
FITC	CSB-PA15457C0Rb	Nsf Antibody, FITC conjugated
Biotin	CSB-PA15457D0Rb	Nsf Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling.

Gene References into Functions

We have found increased expression of NSF gene in basolateral amygdala and perirhinal cortex in groups of rats undergoing taste habituation. PMID: 26839712
TCST increases the expression of NSF in the hippocampus of adult rats with focal cerebral ischemia, which may contribute to the protection of the injured brain. PMID: 25480573
NSF-GluR2 interactions increase in the nucleus accumbens after cocaine withdrawal. PMID: 24599450
a model of NSF-mediated disassembly in which the reaction is initiated by a 1:1 interaction between alpha-SNAP and the ternary SNARE complex, followed by NSF binding. PMID: 23836889
The interaction of N-ethylmaleimide-sensitive factor (NSF) with glutamate receptor 2 (GluR2) is necessary for fear memory consolidation. PMID: 21106836
Synaptic stabilization of AMPA receptors by NSF involves disruption of GluR2-PICK1 interactions. PMID: 11931741
NSF interaction is necessary for rapid incorporation of alpha-amino-3-hydroxy-5-methylisoxazolepropionate (AMPA) receptor subunits into synapses and is sufficient to confer this property on the AMPA receptor GluR3 subunit. PMID: 15797712
These data demonstrate that spontaneous recurrent seizure impairs spatial learning memory and suggest that the down-regulation of NSF expression pattern in the hippocampus and the loss of DA neurons in ventral tegmental area. PMID: 16039622
Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein PMID: 16461345
The functional interaction between three bona fide regulators of neurotransmitter release, such as GABAB receptor (GBR), NEM sensitive fusion (NSF) and Protein Kinase C, could shed new light on the modulation of presynaptic GBR action. PMID: 16724110
A yeast two-hybrid screen using NSF as bait identified Rab11-FIP3 and the Pak-binding nucleotide exchange factor betaPIX as putative binding partners PMID: 16795052
Concomitant with the decrease in NSF, GluR2 and GluR3 were decreased and GluR1 was conversely increased in the postsynaptic density fraction 24 h after complete Freund adjuvant injection PMID: 18598260

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Subcellular Location

Cytoplasm.

Protein Families

AAA ATPase family

Tissue Specificity

Detected in brain (at protein level).

Database Links

KEGG: rno:60355

STRING: 10116.ENSRNOP00000006361

UniGene: Rn.13345

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Related pathways

Synaptic vesicle cycle

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