ODF2 Antibody

Datasheet

Code	CSB-PA016272GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q5BJF6

Target Names

ODF2

Alternative Names

84 kDa outer dense fiber protein antibody; Cancer/testis antigen 134 antibody; Cenexin 1 antibody; Cenexin antibody; Cenexin1 variant 1 antibody; CT134 antibody; FLJ44866 antibody; KKT 4 antibody; KKT4 antibody; MGC111096 antibody; MGC9034 antibody; ODF 2 antibody; ODF 84 antibody; odf2 antibody; ODF2/1 antibody; ODF2/2 antibody; ODF84 antibody; ODFP2_HUMAN antibody; OTTHUMP00000022274 antibody; OTTHUMP00000022275 antibody; Outer dense fiber of sperm tail 2 antibody; Outer dense fiber of sperm tails 2 antibody; Outer dense fiber of sperm tails protein 2 antibody; Outer dense fiber of sperm tails; 84 kD antibody; Outer dense fiber protein 2 antibody; Sperm outer dense fiber major protein 2 antibody; Sperm tail structural protein antibody; Testis specific autoantigen antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human ODF2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC,IP

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunoprecipitation (IP) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.

Gene References into Functions

Cenexin controls centrosome positioning during cell migration by modulating microtubule organization and stability.Cenexin is required for spindle orientation. PMID: 26948879
Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx. PMID: 22911743
Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. PMID: 21325031
Cdk5 in the centriolar appendages mediates cenexin1 localization and primary cilia formation. PMID: 20234188
Mouse and rat ODF2 protein homolog sequences and expression are compared. PMID: 9740324
We propose that hCenexin1 is a critical centrosomal component whose C-terminal extension is required for proper recruitment of Plk1 and other components crucial for normal mitosis. PMID: 16966375
A splice variant of hODF2 called hCenexin1, but not hODF2 itself, efficiently localizes to somatic centrosomes via a variant-specific C-terminal extension and recruits Plk1 through a Cdc2-dependent phospho-S796 motif within the extension. PMID: 19386263

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Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cell projection, cilium, flagellum.

Protein Families

ODF2 family

Tissue Specificity

Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails.

Database Links

HGNC: 8114

OMIM: 602015

KEGG: hsa:4957

STRING: 9606.ENSP00000361882

UniGene: Hs.129055

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