OPTC Antibody, Biotin conjugated

Code CSB-PA016362LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) OPTC Polyclonal antibody
Uniprot No.
Target Names
OPTC
Alternative Names
Oculoglycan antibody; OPT antibody; OPT_HUMAN antibody; OPTC antibody; Opticin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Opticin protein (20-332AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils. May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily.
Gene References into Functions
  1. opticin binds to collagen and thereby competitively inhibits endothelial cell interactions with collagen via alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is required for proangiogenic signaling via these integrins. PMID: 22669977
  2. VEGF and hypoxia could decrease opticin protein levels in the human retinal pigment epithelium secretome, and that opticin may be an enzymatic substrate for MMP-2. PMID: 22534113
  3. localization in the human eye and genetic screen of opticin PMID: 12019215
  4. OPTC is a candidate gene for primary open-angle glaucoma PMID: 17359525
  5. OPTC and EPYC are unlikely to play a major role in high myopia. PMID: 19844586

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Subcellular Location
Secreted, extracellular space, extracellular matrix.
Protein Families
Small leucine-rich proteoglycan (SLRP) family, SLRP class III subfamily
Tissue Specificity
Expressed in cartilage and synovial membranes (at protein level). Expressed in the retina, iris, ligament, skin and fetal liver (at protein level). Expressed in the retinal pigment epithelium (at protein level). Expressed in synovial fibroblasts and subch
Database Links

HGNC: 8158

OMIM: 605127

KEGG: hsa:26254

STRING: 9606.ENSP00000356191

UniGene: Hs.632468

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