OPTC Antibody, HRP conjugated

Code CSB-PA016362LB01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) OPTC Polyclonal antibody
Uniprot No. Q9UBM4
Target Names OPTC
Alternative Names Oculoglycan antibody; OPT antibody; OPT_HUMAN antibody; OPTC antibody; Opticin antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Opticin protein (20-332AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Binds collagen fibrils.
Gene References into Functions
  1. opticin binds to collagen and thereby competitively inhibits endothelial cell interactions with collagen via alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is required for proangiogenic signaling via these integrins. PMID: 22669977
  2. VEGF and hypoxia could decrease opticin protein levels in the human retinal pigment epithelium secretome, and that opticin may be an enzymatic substrate for MMP-2. PMID: 22534113
  3. localization in the human eye and genetic screen of opticin PMID: 12019215
  4. OPTC is a candidate gene for primary open-angle glaucoma PMID: 17359525
  5. OPTC and EPYC are unlikely to play a major role in high myopia. PMID: 19844586

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Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Small leucine-rich proteoglycan (SLRP) family, SLRP class III subfamily
Tissue Specificity Retina, iris, ligament, skin and fetal liver.
Database Links

HGNC: 8158

OMIM: 605127

KEGG: hsa:26254

STRING: 9606.ENSP00000356191

UniGene: Hs.632468

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