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Regulates the differentiation and proliferation through the regulation of cell death.
Gene References into Functions
The results support the concept that smoking-induced upregulation of OSGIN1 is one link between smoking-induced stress and enhanced-autophagy in the human airway epithelium. PMID: 28548877
miR-320a has a role in modulating the induction of HO-1, GCLM and OKL38 by oxidized phospholipids in endothelial cells PMID: 24786516
Identify OSGIN1 as a tumor suppressor that is down-regulated or altered in human hepatocellular carcinoma. PMID: 24417816
Data suggest that OKL38 regulates mitochondria morphology and functions during apoptosis together with p53. PMID: 22912861
Expression in cultured tumor cells resulted in growth inhibition and cell death. PMID: 14570898
BDGI (Bone marrow stromal cell-derived growth inhibitor) inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis [BDGI] PMID: 15569677
The 5'UTRs of OKL38 might play an important role in downregulation of its protein and the absence of OKL38 could lead to the development or progression of hepatocellular carcinoma. PMID: 16924236
identify OKL38 as a novel p53 target gene that is regulated by Peptidylarginine deiminase 4 and plays a role in apoptosis PMID: 18499678
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Protein Families
OKL38 family
Tissue Specificity
Ubiquitous. Highest expression in the ovary, testis, kidney, skeletal muscle and liver. Weakly expressed in spleen, heart, kidney, and pancreas. Highly expressed in tumor cells (at protein level).