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OXER1 Antibody

Datasheet
Code CSB-PA837442LA01HU
Size US$166
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Image
  • CSB-PA837442LA01HU-WB
    Western Blot
    Positive WB detected in: JK whole cell lysate, HL60 whole cell lysate, U937 whole cell lysate
    All lanes: OXER1 antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 46 kDa
    Observed band size: 46 kDa
  • CSB-PA837442LA01HU-IHC-1
    Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA837442LA01HU at dilution of 1:100
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) OXER1 Polyclonal antibody
Uniprot No.
Q8TDS5
Target Names
OXER1
Alternative Names
OXER1; GPR170; TG1019; Oxoeicosanoid receptor 1; 5-oxo-ETE G-protein coupled receptor; G-protein coupled receptor 170; G-protein coupled receptor R527; G-protein coupled receptor TG1019
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Oxoeicosanoid receptor 1 protein (1-97AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The OXER1 Antibody (Product code: CSB-PA837442LA01HU) is Non-conjugated. For OXER1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA837442LB01HU OXER1 Antibody, HRP conjugated ELISA
FITC CSB-PA837442LC01HU OXER1 Antibody, FITC conjugated
Biotin CSB-PA837442LD01HU OXER1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.
Gene References into Functions
  1. These findings verify that membrane-acting androgens exert specific effects through an antagonistic interaction with OXER1. Additionally, this interaction between androgen and OXER1, which is an arachidonic acid metabolite receptor expressed in prostate cancer, provides a novel link between steroid and lipid actions and renders OXER1 as new player in the disease. PMID: 28290516
  2. membrane receptor OxeR1 is involved in StAR protein induction and activation of steroidogenesis triggered by cAMP or angiotensin II, acting, at least in part, through ERK1/2 activation. PMID: 25657046
  3. Gue1654 as a non-Galphai-biased antagonist of OXE-R that provides a new basis for therapeutic intervention in inflammatory diseases that involve activation of eosinophils, neutrophils, and monocytes. PMID: 24733850
  4. OXER1 has a role in regulating the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells PMID: 23643940
  5. Identification of a novel human receptor coupled to G(i/o). PMID: 12065583
  6. identification and cloning of a novel GPCR, R527; 5-oxo-ETE was identified as the ligand for R527; very high level of mRNA expression in eosinophils with high expression also detected in neutrophils and lung macrophages PMID: 12606753
  7. 5-oxoER is critical for prostate cancer cell survival. PMID: 16289380

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Expressed in various tissues except brain. Expression is more intense in liver, kidney, peripheral leukocyte, lung, and spleen than in other tissues. Highly expressed in eosinophils, neutrophils, and lung macrophages.
Database Links

HGNC: 24884

KEGG: hsa:165140

STRING: 9606.ENSP00000367930

UniGene: Hs.168439

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Related pathways
G protein coupled receptor signaling pathway
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