P2RX5 Antibody

1. The amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes. PMID: 25080478
2. These data indicate a functional role of the human P2RX5 splice variant in T cell activation and immunoregulation. PMID: 25181038
3. These findings provide a rationale for use of LRH-1 as immunotherapeutic target antigen to treat residual or persisting myeloid malignancies after allogeneic stem cell transplantation PMID: 19074734
4. Purinergic receptor P2X5 binds to adenosine triphosphate (ATP) to form a molecular complex with ASIC3 (acid-sensing ion channel number 3) to detect muscle ischemia. PMID: 21092862
5. findings indicate that most humans express only a nonfunctional isoform of P2X5, which is in stark contrast to what is seen in other vertebrate species in which P2X5 has been studied, from which only the full-length isoform is known PMID: 20223879
6. Different purinergic receptors have different functional roles in human epidermis with P2Y1 and P2Y2 receptors controlling proliferation, while P2X5 and P2X7 receptors control early differentiation, terminal differentiation and death of keratinocytes. PMID: 12787128
7. Non-melanoma skin cancers express functional purinergic receptors and that P2X7 receptor agonists significantly reduce cell numbers in vitro. PMID: 12880424
8. a P2X5 frameshift mutation has a role in response to treatment of chronic myeloid leukemia PMID: 16322791
9. Increased keratinocyte P2X(5) receptor activity may, in part, be accountable for epidermal thinning in chronic venous insufficiency. PMID: 16967306
10. analysis of topology, helix-helix interactions, and oligomerization of P2X5 subunits PMID: 17001079
11. LRH-1 is aberrantly expressed on solid tumor cells PMID: 18719914

Show More

Hide All

HGNC: 8536

OMIM: 602836

KEGG: hsa:5026

STRING: 9606.ENSP00000225328

UniGene: Hs.731607