P2RY8 Antibody

Code CSB-PA003634
Size US$100
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  • Western Blot analysis of HuvEc cells using P2RY8 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
P2RY8
Alternative Names
P2RY8; P2Y purinoceptor 8; P2Y8
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human P2RY8.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable receptor for purines coupled to G-proteins.
Gene References into Functions
  1. P2RY8-CRLF2 fusion is associated with childhood B-cell acute lymphoblastic leukemia. PMID: 27637012
  2. P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner. PMID: 26573295
  3. P2RY8-CRLF2-positive clones do not have the necessary proliferative or selective advantage to evolve into a disease-relevant relapse clone. PMID: 23091296
  4. Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia. PMID: 22484421
  5. Study reports an extremely high incidence of relapse (71% +/- 19%) in non-high-risk precursor B-cell acute lymphoblastic leukemia patients with P2RY8-CRLF2 rearrangement. PMID: 20378752
  6. P2RY8 is expressed in leukemic cells and has an unexpected role in the pathogenesis of acute leukemia PMID: 17487742
  7. SOX5 is upregulated by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma PMID: 17554380

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.
Database Links

HGNC: 15524

OMIM: 300525

KEGG: hsa:286530

STRING: 9606.ENSP00000370697

UniGene: Hs.111377

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