P2RY8 Antibody

Datasheet

Code	CSB-PA003634
Size	US$119
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Image	Western Blot analysis of HuvEc cells using P2RY8 Polyclonal Antibody
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q86VZ1

Target Names

P2RY8

Alternative Names

P2RY8; P2Y purinoceptor 8; P2Y8

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of Human P2RY8.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IF, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IF	1:200-1:1000
ELISA	1:20000

Protocols

Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Probable receptor for purines coupled to G-proteins.

Gene References into Functions

P2RY8-CRLF2 fusion is associated with childhood B-cell acute lymphoblastic leukemia. PMID: 27637012
P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner. PMID: 26573295
P2RY8-CRLF2-positive clones do not have the necessary proliferative or selective advantage to evolve into a disease-relevant relapse clone. PMID: 23091296
Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia. PMID: 22484421
Study reports an extremely high incidence of relapse (71% +/- 19%) in non-high-risk precursor B-cell acute lymphoblastic leukemia patients with P2RY8-CRLF2 rearrangement. PMID: 20378752
P2RY8 is expressed in leukemic cells and has an unexpected role in the pathogenesis of acute leukemia PMID: 17487742
SOX5 is upregulated by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma PMID: 17554380

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Tissue Specificity

Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.

Database Links

HGNC: 15524

OMIM: 300525

KEGG: hsa:286530

STRING: 9606.ENSP00000370697

UniGene: Hs.111377

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

G protein coupled receptor signaling pathway Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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