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P4HA2 Antibody

Datasheet
Code CSB-PA017340ESR1HU
Size US$166
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  • Western Blotting(WB) - P4HA2 Antibody

    Western blot
    All lanes: P4HA2 antibody at 6μg/ml
    Lane 1: HepG2 whole cell lysate
    Lane 2: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 61 kDa
    Observed band size: 61 kDa

  • Immunohistochemistry(IHC) 1- P4HA2 Antibody

    Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA017340ESR1HU at dilution of 1:100

  • Immunohistochemistry(IHC) 2- P4HA2 Antibody

    Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA017340ESR1HU at dilution of 1:100

  • Immunoprecipitation(IP) - P4HA2 Antibody

    Immunoprecipitating P4HA2 in Hela whole cell lysate
    Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA017340ESR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
    Lane 2: CSB-PA017340ESR1HU (4μg) + Hela whole cell lysate (500μg)
    Lane 3: Hela whole cell lysate (20μg)
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) P4HA2 Polyclonal antibody
Uniprot No.
O15460
Target Names
P4HA2
Alternative Names
2-oxoglutarate-4-dioxygenase subunit alpha-2 antibody; 4 PH alpha 2 antibody; 4-PH alpha-2 antibody; C-P4Halpha(II) antibody; collagen prolyl 4-hydroxylase alpha(II) antibody; P4HA2 antibody; P4HA2_HUMAN antibody; procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide II antibody; procollagen proline, 2 oxoglutarate 4 dioxygenase alpha subunit, isoform 2 antibody; Procollagen-proline antibody; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2 antibody; Prolyl 4 hydroxylase alpha 2 subunit antibody; Prolyl 4 hydroxylase subunit alpha 2 [Precursor] antibody; Prolyl 4-hydroxylase subunit alpha-2 antibody; Prolyl 4-hydroxylase, alpha polypeptide II antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Prolyl 4-hydroxylase subunit alpha-2 protein (236-535AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC, IP
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
IP 1:200-1:2000
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunoprecipitation (IP) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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P4HA2 Antibodies

P4HA2 Proteins

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Target Background

Function
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Gene References into Functions
  1. Assembly of the elongated collagen prolyl 4-hydroxylase alpha2beta2 heterotetramer around a central alapha2 dimer has been reported. PMID: 28093469
  2. Plasminogen and P4HA2 are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis PMID: 28041642
  3. RNAsequencing showed that the t(4;5)(q24;q31) resulted in recombination of the genes TBCK on 4q24 and P4HA2 on 5q31.1 with generation of an inframe TBCKP4HA2 and the reciprocal but outofframe P4HA2TBCK fusion transcripts. PMID: 27633981
  4. P4HA2 was identified as a novel causative gene for nonsyndromic high myopia. PMID: 25741866
  5. Suggest the critical role of P4HA2 in breast cancer progression and identify P4HA2 as a potential therapeutic target and biomarker for breast cancer progression. PMID: 24383403
  6. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. PMID: 23423382
  7. P4HA2 was upregulated in breast tumor cells compared with its adjacent normal tissues. PMID: 22813596
  8. Overexpression of PRDX4 and P4HA2 was significantly associated with lymphatic metastasis in oral cavity squamous cell carcinoma PMID: 21859152
  9. the substrate specificity, binding site and conformation of this enzyme PMID: 12824157
  10. In comparison with healthy cartilage, Osteoarthritis articular chondrocytes exhibit increased in vivo synthesis of collagen prolyl-4-hydroxylase type II, a pivotal enzyme in collagen triple helix formation. PMID: 16877351
  11. HIF-P4H, HIF-1alpha and HIF-2alpha are effective oxygen sensors PMID: 16885164
  12. results show that p53 transcriptionally activates the alpha(II) collagen prolyl-4-hydroxylase [alpha(II)PH] gene, resulting in the extracellular release of antiangiogenic fragments of collagen type 4 and 18 PMID: 16917063

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Involvement in disease
Myopia 25, autosomal dominant (MYP25)
Subcellular Location
Endoplasmic reticulum lumen.
Protein Families
P4HA family
Database Links

HGNC: 8547

OMIM: 600608

KEGG: hsa:8974

STRING: 9606.ENSP00000166534

UniGene: Hs.519568

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