PACSIN2 Antibody

Datasheet
Code CSB-PA890765ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q9UNF0
Image
  • Western blot
    All lanes: PACSIN2 antibody at 5.29µg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 56, 52 kDa
    Observed band size: 56 kDa

  • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA890765ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA890765ESR2HU at dilution of 1:100

Immunogen Recombinant Human Protein kinase C and casein kinase substrate in neurons protein 2 protein (240-410AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200
Relevance Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II), PACSIN2
Immunogen Species Human
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Research Area Signal Transduction
Target Names PACSIN2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
Subcellular Location Cytoplasm, Cytoplasm, cytoskeleton, Cytoplasmic vesicle membrane, Peripheral membrane protein, Cytoplasmic side, Early endosome, Recycling endosome membrane, Cell projection, ruffle membrane, Peripheral membrane protein, Cytoplasmic side, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, Membrane, caveola
Protein Families PACSIN family
Tissue Specificity Widely expressed.
Database Links

HGNC: 8571

OMIM: 604960

KEGG: hsa:11252

STRING: 9606.ENSP00000263246

UniGene: Hs.162877

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