PAF1 Antibody

1. a subset of enhancers can primarily modulate gene expression by controlling the release of paused Pol II in a PAF1-dependent manner. PMID: 28860207
2. These results reveal ubiquitin-proteasome system regulation of Paf1 and suggest downregulation of ubiquitin-proteasome system in elevating Paf1's abundance in poorly differentiated cancers. PMID: 29023102
3. The various functions of Paf1C, such as the regulation of promoter-proximal pausing and development in higher eukaryotes, are complex and context dependent. PMID: 28870425
4. High PAF1 expression is associated with ovarian cancer. PMID: 28122356
5. Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma. PMID: 26689992
6. Propose that degradation of MYC limits the accumulation of MYC/PAF1C complexes during transcriptional activation. PMID: 26687678
7. Mechanistic studies indicated that PAF1C could promote lung cancer cell proliferation through regulating c-MYC transcription. PMID: 26282204
8. CNOT4 controls the degradation of chromatin-unbound PAF1 via the 26S proteasome. PMID: 25933433
9. this study found that Pol II-associated factor 1 (PAF1) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) directly regulates the initial recruitment of PAF1 complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 is dependent on PAF1C. PMID: 26659056
10. This study reveals an evolutionarily conserved role for PAF1 as a regulator of promoter-proximal pausing by RNA Pol II in all metazoans, including human. PMID: 26279188
11. PD2 is a novel cancer stem cell (CSC) maintenance protein, loss of which renders the CSCs more susceptible to drug-induced cell death. PMID: 25003666
12. Together, these results indicate that human adenovirus E1A uses hBre1 to recruit the hPaf1 complex in order to optimally activate viral early transcription by enhancing transcriptional elongation. PMID: 24600005
13. The results show that the Paf1/Leo1 heterodimer is necessary for its binding to histone H3, the histone octamer, and nucleosome in vitro. PMID: 24038468
14. E1A changes the function of hBre1 from a ubiquitin ligase involved in substrate selection to a scaffold which recruits hPaf1 as a means to stimulate transcription and transcription-coupled histone modifications. PMID: 23785282
15. Data indicate that the Plus3 domain of the Rtf1 subunit mediates Paf1C recruitment to genes by binding a repeating domain within the phosphorylated elongation factor Spt5. PMID: 24101474
16. Data show that activation-induced deaminase (AID) associates with RNA polymerase-associated factor 1 (PAF1) through its N-terminal domain. PMID: 23008333
17. PAF1c acts as an arginine methyl histone effector that is recruited to promoters and activates a subset of genes, including targets of estrogen signaling. PMID: 22451921
18. that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells PMID: 22046413
19. Interaction between the Polymerase Associated Factor complex and Mixed Lineage Leukemia is critical for gene rearranged leukemogenesis. PMID: 21037944
20. MLL interacts directly with the polymerase associated factor complex (PAFc) via Paf1 and CTR9. PAFc augments MLL and MLL-AF9 mediated transcriptional activation of Hoxa9 and their interaction is essential for leukemogenesis. PMID: 20541477
21. Study demonstrates the ability of human PAF1C to facilitate activator p53- and histone acetyltransferase p300-dependent transcription elongation from a recombinant chromatin template in a biochemically defined RNA polymerase II transcription system. PMID: 20178742
22. hPaf1 and the hPAF complex are key regulators of cell-cycle progression PMID: 19771162
23. Formation of trimeric complex UbcH6 and RNF20/40 with PAF stimulates histone 2B monoubiquitination activity in vitro PMID: 16307923
24. Overexpression of PD2/hPaf1 is involved in cancer development. PMID: 16491129

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HGNC: 25459

OMIM: 610506

KEGG: hsa:54623

STRING: 9606.ENSP00000221265

UniGene: Hs.466714