PANX2 Antibody

Code CSB-PA839405LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: HepG2 whole cell lysate, K562 whole cell lysate, Rat liver tissue, Mouse liver tissue
    All lanes: PANX2 antibody at 4.2µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 75, 71, 56 kDa
    Observed band size: 75 kDa

  • IHC image of CSB-PA839405LA01HU diluted at 1:400 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of HepG2 cells with CSB-PA839405LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PANX2 Polyclonal antibody
Uniprot No.
Target Names
PANX2
Alternative Names
PANX2; Pannexin-2
Raised in
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human Pannexin-2 protein (370-470AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PANX2 Antibody (Product code: CSB-PA839405LA01HU) is Non-conjugated. For PANX2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA839405LB01HU PANX2 Antibody, HRP conjugated ELISA
FITC CSB-PA839405LC01HU PANX2 Antibody, FITC conjugated
Biotin CSB-PA839405LD01HU PANX2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Structural component of the gap junctions and the hemichannels.
Gene References into Functions
  1. The pannexin 2 (Panx2) N86Q mutant is glycosylation-deficient and tends to aggregate in the endoplasmic reticulum (ER)reducing its cell surface trafficking but it can still interact with pannexin 1 (Panx1). PMID: 29932112
  2. All three pannexins Panx1, Panx2, and Panx3 mRNAs were expressed in all of the analyzed undifferentiated stem cell lines. PMID: 29357945
  3. Panx2 mRNA and protein levels were only upregulated in focal cortical dysplasia type IIb lesions of intractable epilepsy patients and characteristically expressed on SOX2-positive multipotential balloon cells. PMID: 28036289
  4. Panx2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic beta-cells. PMID: 28390953
  5. The results of this study do not support a major contribution of PANX1-3 to disease risk of schizophrenia according to DSM-5. PMID: 26223428
  6. There is dense expression of Panx2 in the enteric nervous system. The substantial increase in Panx2 mRNA in ulcerative colitis (UC) muscle but not protein suggests that the Panx2 translation process may be disrupted in UC. PMID: 25773474
  7. Data suggest that both up-regulation and down-regulation of expression of pannexins (PANX1, PANX2, PANX3) are associated with disease onset and/or progression; examples include neoplasms, multiple sclerosis, migraine, and hypertension. [REVIEW] PMID: 25008946
  8. Panx1 and Panx2 expression was detected in the temporal lobe cortex of patients with temporal lobe epilepsy and in the control tissues. PMID: 24146091
  9. Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other PMID: 20516070
  10. These data do not suggest that Panx2 or Cx36 could increase the risk of schizophrenia in the Japanese population. PMID: 17427027
  11. Pannexin2 is a tumor suppressor gene in C6 glioma cells. PMID: 19749789
  12. According to brain cancer gene expression database REMBRANDT, PANX2 expression levels can predict post diagnosis survival for patients with glial tumors. PMID: 16989724

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein Families
Pannexin family
Database Links

HGNC: 8600

OMIM: 608421

KEGG: hsa:56666

STRING: 9606.ENSP00000379183

UniGene: Hs.440092

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