PCSK2 Antibody

Datasheet

Code	CSB-PA017642LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, U251 whole cell lysate, Mouse lung tissue All lanes: Pcsk1 antibody at 8μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 85 kDa Observed band size: 85 kDa IHC image of CSB-PA017642LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA017642LA01HU diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PCSK2 Polyclonal antibody

Uniprot No.

P16519

Target Names

PCSK2

Alternative Names

KEX2 like endoprotease 2 antibody; KEX2-like endoprotease 2 antibody; NEC 2 antibody; NEC2 antibody; NEC2_HUMAN antibody; Neuroendocrine convertase 2 antibody; PC2 antibody; PCSK2 antibody; Prohormone convertase 2 antibody; Proprotein convertase 2 antibody; Proprotein convertase subtilisin/kexin type 2 antibody; SPC2 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Neuroendocrine convertase 2 protein (267-391AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PCSK2 Antibody (Product code: CSB-PA017642LA01HU) is Non-conjugated. For PCSK2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA017642LB01HU	PCSK2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017642LC01HU	PCSK2 Antibody, FITC conjugated
Biotin	CSB-PA017642LD01HU	PCSK2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.

Gene References into Functions

PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes. PMID: 26607656
FAM20C plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing. PMID: 25811241
in the processing of hypothalamic neuropeptides in huntington disease may partially arise from decreased PC1/3 and PC2 expressions. PMID: 24226266
variant of the PCSK2 gene was associated with reduced glucose-stimulated insulin secretion, but also with lower glucagon levels, which could potentially counteract the effects of decreased insulin secretion on the risk of type 2 diabetes PMID: 23011353
The association of risk allele rs2021785 at PCSK2 with type 2 diabetes exists in a Han Chinese population PMID: 21437630
differential gene expression profiles revealed more abundant mRNA expression in ectopic ACTH syndrome than in Cushing disease of proprotein convertase-2 PMID: 21383526
PC1/3 governs the endocrine, and PC2 the neuronal processing, of proCCK, whereas PC5/6 contributes only to a modest endocrine synthesis of CCK-22. PMID: 18096669
SEMA3F, CLEC16A, LAMA3, and PCSK2 variants have roles in myocardial infarction in Japanese individuals PMID: 20036365
A marked decrease in the ratio of the PC2 precursor to the total enzymatic pool is observed in the frontal cortex of Alzheimer patients; however, the content and enzymatic activity of the PC2 mature form are similar in Alzheimer patients and controls. PMID: 14614908
concluded that there are two novel TRE-like sequences in the hPC2 promoter and that these regions act in concert in a unique manner to facilitate the effects of thyroid hormone and 9-cis-retinoic acid on PC2 PMID: 15585599
Single nucleotide polymorphisms in PCSK2 is associated with type 2 diabetes PMID: 17618154

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Subcellular Location

Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Localized in the secretion granules.

Protein Families

Peptidase S8 family, Furin subfamily

Database Links

HGNC: 8744

OMIM: 162151

KEGG: hsa:5126

STRING: 9606.ENSP00000262545

UniGene: Hs.315186

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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