PDZK1 Antibody

1. PDZK1 directly interacts with OATP2B1 resulting in a change of the amount of transporter in the membrane, and thereby in an increased transport function. PMID: 29752999
2. These findings have provided first lines of evidences that PDZK1 expression is negatively correlated with SHP-1 activation and poor clinical outcomes in clear cell renal cell carcinoma (ccRCC) . PDZK1 was identified as a novel tumor suppressor in ccRCC by negating SHP-1 activity PMID: 28692056
3. HNF1alpha, which has previously been described as a modulator of several transporters of the renal transportosome, is also a key determinant of PDZK1 transcription. PMID: 28724612
4. a PDZK1 single nucleotide polymorphism rs12129861 was found to be significantly associated with gout susceptibility (meta-analysis) PMID: 27720648
5. PDZK1 was defined as an independent prognostic factor for both OS and DFS. These findings indicated that low level of PDZK1 could predict poor clinical outcome in patients with ccRCC. PMID: 27993630
6. Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 dysfunction observed in the inflamed intestine. PMID: 25271043
7. PARP regulates estradiol-mediated cell growth by controlling the ER/IGF-1R/PDZK1 axis. PMID: 26183824
8. PDZKA1 adaptor protein gene of urate transporters, is not associated with gout. PMID: 25362723
9. PDZK1, negatively regulates 5-HT2AR endocytosis and has no effect upon 5-HT2AR-mediated ERK1/2 phosphorylation. PMID: 25562428
10. Described is a structure of D-AKAP2 in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta-strand to PDZK1. PMID: 25348485
11. PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability. PMID: 24728453
12. Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37 PMID: 24869908
13. IRF3 activation by innate antiviral signaling represses TGF-beta-induced growth inhibition, gene regulation and epithelial-mesenchymal transition, and the generation of Treg effector lymphocytes from naive CD4(+) lymphocytes. PMID: 25526531
14. NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules. PMID: 24436471
15. These results clarify the relationship between ER-alpha and PDZK1, propose a direct relationship between PDZK1 and IGF1R, and identify a novel oncogenic activity for PDZK1 in breast cancer. PMID: 23821363
16. Antibody screening revealed 3 candidate prognostic markers in breast cancer: the Anillin (ANLN); PDZ-Binding Kinase (PBK); and, PDZ-Domain Containing 1 (PDZK1). PMID: 23547718
17. Upregulation of PDZK1 could have an important role in the development of melasma in connection with estrogen through NHE, CFTR, and SLC26A3. PMID: 22696060
18. PDZ domain-containing 1 (PDZK1) protein regulates phospholipase C-beta3 (PLC-beta3)-specific activation of somatostatin by forming a ternary complex with PLC-beta3 and somatostatin receptors. PMID: 22528496
19. Human prostacyclin receptor interacts with the PDZ adapter protein PDZK1; this interaction plays important role in endothelial cell migration and angiogenesis. PMID: 21653824
20. Although PDZK1 binding is required for optimal cell surface expression of oatp1a1, phosphorylation provides a mechanism for fast regulation of the distribution of oatp1a1 between the cell surface and intracellular vesicular pools. PMID: 21183661
21. The SR-BI partner PDZK1 facilitates hepatitis C virus entry. PMID: 20949066
22. Data show that PDZK1/EBP50/ezrin form a regulated ternary complex in vitro and in vivo. PMID: 20237154
23. Overexpression of PDZK1 is associated with a drug-resistance phenotype in multiple myeloma. PMID: 15215163
24. PDZK1 plays a role in regulating the functional activity of URAT1-mediated urate transport in the apical membrane of renal proximal tubules. PMID: 15304510
25. We have examined the ability of Bcr to interact with other epithelial PDZ proteins and found specific binding to both the apical PDZK1 protein and the Golgi-localized Mint3 PMID: 15494376
26. Double transfection of OCTN2 with PDZK1 intestinal and kidney-enriched PDZ protein))stimulated the uptake by OCTN2 of its endogenous substrate carnitine. PMID: 15523054
27. oligomerization of Oatp1a1 with PDZK1 is critical for its proper subcellular localization and function PMID: 15994332
28. intracellular sorting of the somatostatin receptor subtype 5 is regulated by interactions with PDZ domain proteins PIST/GOPC and PDZK1 PMID: 16012170
29. PEPT2-PDZK1 interaction thus plays a physiologically important role in both oligopeptide handling as well as peptide-like drug transport in the human kidney PMID: 16738539
30. The interaction of PDZ proteins with hOAT4 may be cell-specific. In placenta, a different set of interacting proteins from PDZK1 and NHERF1 may be required to modulate hOAT4 activity. PMID: 17602283
31. Pdzk1 plays a specific role in stabilizing Muc17 in the apical membrane of small intestinal enterocytes. PMID: 17990980
32. Established a mouse model to study human reverse cholesterol transport by expressing CLA-1, human PDZK1, and human apoA-I gene. PMID: 18403724
33. Endogenous PPARalpha regulates PDZK1 expression. PMID: 18955051
34. While the presence of forskolin results in an increase in OCTN2 protein expression, the increase in uptake capacity may be compensated by the decreased expression of PDZK1, NHERF1 or NHERF2. PMID: 19091402
35. The tail of PDZK1 interacts with the PDZ domains of EBP50, and this interaction is negatively regulated by the intramolecular association of the tail of PDZK1 with its first PDZ domain. PMID: 19173579
36. findings suggest that PDZ domain containing 1 (PDZK1)_i33968C > T genetic variants may be associated with a higher risk of exhibiting metabolic syndrome PMID: 19321583
37. In HEK cells, which express little PDZK1, additional transfection of PDZK1 was required for UTP to inhibit DRA. PMID: 19447883
38. NHERF3 colocalizes and directly binds NHE3 at the plasma membrane under basal conditions. PMID: 19535329

Show More

Hide All

HGNC: 8821

OMIM: 603831

KEGG: hsa:5174

STRING: 9606.ENSP00000342143

UniGene: Hs.444751