PES1 Antibody

Code CSB-PA017791LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Mouse heart tissue
    All lanes: PES1 antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 69, 68 kDa
    Observed band size: 69 kDa

  • Immunofluorescent analysis of PC-3 cells using CSB-PA017791LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PES1 Polyclonal antibody
Uniprot No.
Target Names
PES1
Alternative Names
FLJ43790 antibody; Homo sapiens pescadillo mRNA complete cds antibody; PES antibody; PES 1 antibody; pes1 antibody; PESC_HUMAN antibody; Pescadillo (zebrafish) homolog 1 containing BRCT domain antibody; Pescadillo homolog 1 antibody; Pescadillo homolog 1 containing BRCT domain (zebrafish) antibody; Pescadillo homolog antibody; Pescadillo ribosomal biogenesis factor 1 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Pescadillo homolog protein (378-588AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PES1 Antibody (Product code: CSB-PA017791LA01HU) is Non-conjugated. For PES1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA017791LB01HU PES1 Antibody, HRP conjugated ELISA
FITC CSB-PA017791LC01HU PES1 Antibody, FITC conjugated
Biotin CSB-PA017791LD01HU PES1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Gene References into Functions
  1. posttranslational modification of PES1 by SUMOylation may serve as a key factor that regulates the function of PES1 in vivo PMID: 27409667
  2. PES1 may play an important role in development of gastric cancer. PMID: 26423399
  3. PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERalpha and ERbeta expression. PMID: 24376209
  4. these results uncover a potential role of PES1 in chemoresistance by regulating DNA damage response in colorectal cancer cells. PMID: 23333390
  5. Upstream of c-Jun, it was revealed that c-Jun NH2-terminal kinases (JNK) is essential for controlling PES1 expression PMID: 22860098
  6. expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer PMID: 22820289
  7. The physical interaction between B23 and PES1 implies that they may participate in ribosome biogenesis in a protein complex. PMID: 20011973
  8. pescadillo might play a role in promoting the proliferation and carcinogenesis of human breast cancer, and thereby might be a potential target for human breast cancer treatment. PMID: 19764998
  9. Mechanisms for the ability of Pes1 to transform cells, and its failure to immortalize them. PMID: 15273728
  10. RRB1 interacts with YPH1 (yeast pescadillo homologue 1) and other members of the Yph1 complex PMID: 15467761
  11. Pes1 and Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex). PMID: 16043514
  12. Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association. PMID: 17353269

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Subcellular Location
Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome.
Protein Families
Pescadillo family
Tissue Specificity
Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
Database Links

HGNC: 8848

OMIM: 605819

KEGG: hsa:23481

STRING: 9606.ENSP00000346725

UniGene: Hs.517543

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