PFKFB2 Antibody

Datasheet

Code	CSB-PA017818LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA017818LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA017818LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: K562 whole cell lysate, Rat kidney tissue, Rat brain tissue All lanes: PFKFB2 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 59, 55 kDa Observed band size: 55 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PFKFB2 Polyclonal antibody

Uniprot No.

O60825

Target Names

PFKFB2

Alternative Names

6 phosphofructo 2 kinase/fructose 2 6 biphosphatase 2 antibody; 6-bisphosphatase antibody; 6-P2ase 2 antibody; 6-P2ASE heart-type isozyme antibody; 6PF 2 K/Fru 2 6 P2ASE heart type isozyme antibody; 6PF-2-K/Fru-2 antibody; 6PF-2-K/Fru-26-P2ase 2 antibody; 6PF-2-K/Fru-26-P2ase heart-type isozyme antibody; F262_HUMAN antibody; Fructose 2 6 bisphosphatase cardiac isozyme antibody; Fructose-2 antibody; PFK 2/FBPase 2 antibody; PFK/FBPase 2 antibody; PFKFB cardiac antibody; PFKFB2 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 protein (360-505AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PFKFB2 Antibody (Product code: CSB-PA017818LA01HU) is Non-conjugated. For PFKFB2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA017818LB01HU	PFKFB2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017818LC01HU	PFKFB2 Antibody, FITC conjugated
Biotin	CSB-PA017818LD01HU	PFKFB2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Synthesis and degradation of fructose 2,6-bisphosphate.

Gene References into Functions

UCA1/miR-182/PFKFB2 axis modulates chemokine CXCL14 secretion, glycolysis and invasion of glioma cells in glioblastoma-associated stromal cells . PMID: 29655792
Crystal structure of human and cattle heart PFKFB2 and the inhibitory influence of citrate on substrate binding has been described. PMID: 27802586
Variation in PFKFB2 appears to reduce PFKFB2 expression in adipose and kidney tissues, and thereby increase risk for adiposity and diabetic nephropathy. PMID: 25662186
Highly expressed PFKFB2 protein is associated with hepatocellular carcinoma. PMID: 24568531
bifunctionality of PFK-2/FBPase-2 complements the metabolic zonation of the liver by ensuring coherent switching in response to insulin and glucagon. PMID: 24634222
amino acids stimulate Fru-2,6-P2 synthesis by Akt-dependent PFKFB2 phosphorylation and activation and show how signaling and metabolism are inextricably linked. PMID: 23457334
A persistent increase in 6-phosphofructo-2-kinase produced by a change in PFK-2/FBPase-2 isoform expression that may play an important role in the regulation of muscle glycolysis. PMID: 22241065
Suggest that PFKFB2 is not an essential upstream regulator of the anti-leukemic effects of glucocorticoids. PMID: 21092265
induction of de novo lipid synthesis by androgen requires transcriptional up-regulation of HK2 and PFKFB2, and phosphorylation of PFKFB2 generated by the PI3K/Akt signal pathway to supply the source for lipogenesis from glucose in prostate cancer cells. PMID: 20958264
Human islets expressed the PFKFB2 and PFKFB3 isoforms. PFK-2/FBPase-2 protein rather than its product fructose 2,6-P(2) is the over-riding determinant of glucose-induced insulin secretion through regulation of glucokinase activity PMID: 18039179

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Protein Families

Phosphoglycerate mutase family

Tissue Specificity

Heart.

Database Links

HGNC: 8873

OMIM: 171835

KEGG: hsa:5208

STRING: 9606.ENSP00000356047

UniGene: Hs.282702

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

AMPK signaling

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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