PHKA1 Antibody, FITC conjugated

Code CSB-PA017922LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PHKA1 Polyclonal antibody
Uniprot No.
Target Names
PHKA1
Alternative Names
5330411D17 antibody; 9830108K24Rik antibody; kinase PHKA1 antibody; KPB1 antibody; KPB1_HUMAN antibody; MGC132604 antibody; Pcyt1b antibody; PHKA antibody; PHKA1 antibody; Phosphorylase b kinase regulatory subunit alpha antibody; Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform antibody; Phosphorylase kinase alpha M subunit antibody; phosphorylase kinase, alpha 1 (muscle) antibody; RP23 210E20.1 antibody; skeletal muscle isoform antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform protein (555-688AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
Gene References into Functions
  1. muscle PHKA deficiency may present as an almost asymptomatic condition, despite a mild impairment of muscle PMID: 22238410
  2. alpha- and beta-subunits possess amino-terminal glucoamylase-like domains and suggests that they might possess a previously overlooked amylase activity PMID: 12876330
  3. X-linked PHK deficiency causes a mild metabolic myopathy with blunted muscle glycogen breakdown and impaired lactate production during dynamic exercise, which impairs oxidative capacity only marginally PMID: 18401027
Involvement in disease
Glycogen storage disease 9D (GSD9D)
Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein Families
Phosphorylase b kinase regulatory chain family
Tissue Specificity
Muscle specific. Isoform 1 is predominant in vastus lateralis muscle. Isoform 2 predominates slightly in heart, and it predominates clearly in the other tissues tested.
Database Links

HGNC: 8925

OMIM: 300559

KEGG: hsa:5255

STRING: 9606.ENSP00000362643

UniGene: Hs.201379

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