PHKA1 Antibody

Datasheet

Code	CSB-PA017922LA01HU
Size	US$166
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Image	IHC image of CSB-PA017922LA01HU diluted at 1:500 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PHKA1 Polyclonal antibody

Uniprot No.

P46020

Target Names

PHKA1

Alternative Names

5330411D17 antibody; 9830108K24Rik antibody; kinase PHKA1 antibody; KPB1 antibody; KPB1_HUMAN antibody; MGC132604 antibody; Pcyt1b antibody; PHKA antibody; PHKA1 antibody; Phosphorylase b kinase regulatory subunit alpha antibody; Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform antibody; Phosphorylase kinase alpha M subunit antibody; phosphorylase kinase, alpha 1 (muscle) antibody; RP23 210E20.1 antibody; skeletal muscle isoform antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform protein (555-688AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PHKA1 Antibody (Product code: CSB-PA017922LA01HU) is Non-conjugated. For PHKA1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA017922LB01HU	PHKA1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017922LC01HU	PHKA1 Antibody, FITC conjugated
Biotin	CSB-PA017922LD01HU	PHKA1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

Gene References into Functions

muscle PHKA deficiency may present as an almost asymptomatic condition, despite a mild impairment of muscle PMID: 22238410
alpha- and beta-subunits possess amino-terminal glucoamylase-like domains and suggests that they might possess a previously overlooked amylase activity PMID: 12876330
X-linked PHK deficiency causes a mild metabolic myopathy with blunted muscle glycogen breakdown and impaired lactate production during dynamic exercise, which impairs oxidative capacity only marginally PMID: 18401027

Involvement in disease

Glycogen storage disease 9D (GSD9D)

Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side.

Protein Families

Phosphorylase b kinase regulatory chain family

Tissue Specificity

Muscle specific. Isoform 1 is predominant in vastus lateralis muscle. Isoform 2 predominates slightly in heart, and it predominates clearly in the other tissues tested.

Database Links

HGNC: 8925

OMIM: 300559

KEGG: hsa:5255

STRING: 9606.ENSP00000362643

UniGene: Hs.201379

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Calcium signaling pathway Glucagon signaling pathway Insulin signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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