PHOSPHO1 Antibody

Datasheet

Citations (4)

Code	CSB-PA819461LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA819461LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA819461LA01HU at dilution of 1:100
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Product Details
Citations
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PHOSPHO1 Polyclonal antibody

Uniprot No.

Q8TCT1

Target Names

PHOSPHO1

Alternative Names

PHOP1_HUMAN antibody; Phosphatase orphan 1 antibody; Phospho 1 antibody; phospho1 antibody; Phosphoethanolamine/phosphocholine phosphatase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Phosphoethanolamine/phosphocholine phosphatase protein (1-267AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PHOSPHO1 Antibody (Product code: CSB-PA819461LA01HU) is Non-conjugated. For PHOSPHO1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA819461LB01HU	PHOSPHO1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA819461LC01HU	PHOSPHO1 Antibody, FITC conjugated
Biotin	CSB-PA819461LD01HU	PHOSPHO1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Citations

Histochemical analysis of osteoclast and osteoblast distributions on hydroxyapatite/collagen bone-like nanocomposite embedded in rat tibiae M Sakakibara, T Hasegawa,Journal of Oral Biosciences,2025
Histochemical assessment of the femora of Spontaneously Diabetic Torii-Leprfa (SDT-fa/fa) rats that mimic type II diabetes Q Yao, K Tsuboi, H Hongo, M Sakakibara,Journal of Oral Biosciences,2024
Abaloparatide promotes bone repair of vertebral defects in ovariectomized rats by increasing bone formation A Makino,Bone,2024
Differential osteoblastic activity in primary metaphyseal trabecular and secondary trabeculae of c-fos deficient mice T Yamamoto,Journal of oral biosciences,2023

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

Submit a Review here

Applications : Immunohistochemistry

Sample type: cells

Review: PHOSPHO1-positive cells could be hardly seen on the c-fos_x005f/ secondary trabeculaeM.

By Anonymous

Target Background

Function

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix.

Gene References into Functions

CpG sites located in PHOSPHO1 gene showed differential methylation in association with lipid traits. Genetic variants in PHOSPHO1 gene were also associated with lipid profile. PMID: 28173150
DNA methylation at the PHOSPHO1 locus cg02650017 in blood DNA was associated with a decreased risk for future type 2 diabetes. PMID: 27148772
REVIEW: role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification PMID: 24533943
Models of PHOSPHO2 and PHOSPHO1 suggest subtle differences in the charge distributions around the putative substrate entry site and in the location of potential H-bond donors. PMID: 16054448
The identification of a novel, alternatively spliced PHOSPHO1 transcript (PHOSPHO1-3a), was described. PMID: 18471996

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Subcellular Location

Extracellular vesicle.

Protein Families

HAD-like hydrolase superfamily, PHOSPHO family

Tissue Specificity

Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize.

Database Links

HGNC: 16815

KEGG: hsa:162466

STRING: 9606.ENSP00000406909

UniGene: Hs.405607

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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