Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Gene References into Functions
We propose that protein complexes assembled by the R2TP complex are defined by phosphorylation of a specific motif and recognition by the PIH1D1 subunit PMID: 24656813
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription. PMID: 24036451
Human PIH1 domain-containing protein 1 (PIH1) interacts directly with histone H4 and recruits the Brg1-SWI/SNF complex via SNF5 to human rRNA genes. PMID: 22368283
this study investigated the interaction between RPAP3 and PIH1D1. PMID: 23159623
PIH1D1 may stabilize SNF5 by attenuating its proteasome degradation pathway. PMID: 20078948
These results suggest that PIH1D1 may also function as a novel modulator of apoptosis pathway. PMID: 21078300
Is part of an RNA polymerase II-associated complex with possible chaperone activity. PMID: 19450687
Show More
Hide All
Subcellular Location
Nucleus.
Protein Families
PIH1 family
Tissue Specificity
Expressed at low levels in normal mammary epithelial cells (at protein level). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen