PIK3AP1 Antibody, HRP conjugated

Code CSB-PA747806LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PIK3AP1 Polyclonal antibody
Uniprot No.
Target Names
PIK3AP1
Alternative Names
PIK3AP1 antibody; BCAPPhosphoinositide 3-kinase adapter protein 1 antibody; B-cell adapter for phosphoinositide 3-kinase antibody; B-cell phosphoinositide 3-kinase adapter protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Phosphoinositide 3-kinase adapter protein 1 protein (293-404AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Gene References into Functions
  1. Dimeric BCAP associates with the TIR domains of TLR2/4 and MAL/TIRAP, suggesting that it is recruited to the TLR signalosome by multitypic TIR-TIR interactions. PMID: 27909057
  2. Abi-1 promotes Abl-mediated BCAP phosphorylation and suggest that Abi-1 in general coordinates kinase-substrate interactions PMID: 15893754
Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein.
Tissue Specificity
Expressed in natural killer (NK) cells.
Database Links

HGNC: 30034

OMIM: 607942

KEGG: hsa:118788

STRING: 9606.ENSP00000339826

UniGene: Hs.310456

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