PINK1 Antibody

Datasheet
Code CSB-PA447054
Size US$299
Uniprot No. Q9BXM7
Image
  • Gel: 10%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA447054(PINK1 Antibody) at dilution 1/125 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 seconds
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Synthetic peptide of Human PINK1
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,WB;ELISA:1:2000-1:5000,WB:1:500-1:2000
Relevance This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias PTEN induced putative kinase 1
Immunogen Species Homo sapiens (Human)
Target Names PINK1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN
Involvement in disease Parkinson disease 6 (PARK6)
Subcellular Location Mitochondrion outer membrane, Single-pass membrane protein, Mitochondrion inner membrane, Single-pass membrane protein, Cytoplasm, cytosol
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family
Tissue Specificity Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
Database Links

HGNC: 14581

OMIM: 168600

KEGG: hsa:65018

STRING: 9606.ENSP00000364204

UniGene: Hs.389171

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