PINK1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA863144LD01HU
Size US$299
Uniprot No. Q9BXM7
Protocols ELISA Protocol
Immunogen Recombinant Human Serine/threonine-protein kinase PINK1, mitochondrial protein (162-272AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1), PINK1
Immunogen Species Human
Research Area Neuroscience
Target Names PINK1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN
Involvement in disease Parkinson disease 6 (PARK6)
Subcellular Location Mitochondrion outer membrane, Single-pass membrane protein, Mitochondrion inner membrane, Single-pass membrane protein, Cytoplasm, cytosol
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family
Tissue Specificity Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
Database Links

HGNC: 14581

OMIM: 168600

KEGG: hsa:65018

STRING: 9606.ENSP00000364204

UniGene: Hs.389171

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