PITPNA Antibody

Datasheet

Code	CSB-PA018035LA01HU
Size	US$166
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Image	IHC image of CSB-PA018035LA01HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of U251 cells with CSB-PA018035LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PITPNA Polyclonal antibody

Uniprot No.

Q00169

Target Names

PITPNA

Alternative Names

MGC99649 antibody; Phosphatidylinositol transfer protein alpha antibody; Phosphatidylinositol transfer protein alpha isoform antibody; Phosphotidylinositol transfer protein antibody; PI-TP-alpha antibody; PIPNA_HUMAN antibody; PITP alpha antibody; Pitpna antibody; PITPNB antibody; PtdIns transfer protein alpha antibody; PtdInsTP alpha antibody; PtdInsTP antibody; Vb antibody; VIB1A antibody; Vibrator antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Phosphatidylinositol transfer protein alpha isoform protein (1-270AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PITPNA Antibody (Product code: CSB-PA018035LA01HU) is Non-conjugated. For PITPNA Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA018035LB01HU	PITPNA Antibody, HRP conjugated	ELISA
FITC	CSB-PA018035LC01HU	PITPNA Antibody, FITC conjugated
Biotin	CSB-PA018035LD01HU	PITPNA Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3.

Gene References into Functions

Data show that phosphatidylinositol transfer protein alpha (PITPalpha) is involved in the function of mixed lineage kinase domain-like protein (MLKL) in necroptosis. PMID: 29104146
the PITPalpha structure has to relax to allow access to the Ser166 site, and this may occur at the membrane surface where PI delivery is required for receptor-mediated PLC signaling PMID: 15322105
the apparent occurrence of an unusual TG 3' splice site in intron 4 is discussed PMID: 17672918

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

PtdIns transfer protein family, PI transfer class I subfamily

Database Links

HGNC: 9001

OMIM: 600174

KEGG: hsa:5306

STRING: 9606.ENSP00000316809

UniGene: Hs.429819

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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