Name: PITPNM1 Antibody
Brand: CUSABIO
SKU: CSB-PA01995A0Rb

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PITPNM1 Polyclonal antibody

Uniprot No.

O00562

Target Names

PITPNM1

Alternative Names

DRES9 antibody; Drosophila retinal degeneration B antibody; Drosophila retinal degeneration B homolog antibody; FLJ44997 antibody; membrane-associated 1 antibody; Membrane-associated phosphatidylinositol transfer protein 1 antibody; NIR 2 antibody; NIR-2 antibody; NIR2 antibody; OTTHUMP00000236414 antibody; OTTHUMP00000236415 antibody; Phosphatidylinositol transfer protein antibody; phosphatidylinositol transfer protein membrane associated antibody; PITM1_HUMAN antibody; PITPnm 1 antibody; PITPNM antibody; Pitpnm1 antibody; PYK2 N terminal domain interacting receptor 2 antibody; Pyk2 N-terminal domain-interacting receptor 2 antibody; RD 9 antibody; RD9 antibody; RDGB antibody; RDGB1 antibody; RDGBA1 antibody; retinal degeneration B alpha 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Membrane-associated phosphatidylinositol transfer protein 1 protein (1-238AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PITPNM1 Antibody (Product code: CSB-PA01995A0Rb) is Non-conjugated. For PITPNM1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA01995B0Rb	PITPNM1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA01995C0Rb	PITPNM1 Antibody, FITC conjugated
Biotin	CSB-PA01995D0Rb	PITPNM1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Catalyzes the transfer of phosphatidylinositol (PI) between membranes. Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC. Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.

Gene References into Functions

results suggest that Nir2 not only enhances EMT in vitro and breast cancer metastasis in animal models, but also contributes to breast cancer progression in human patients. PMID: 25179602
Phosphatidic acid production triggers Phosphatidylinositol 4,5-Bisphosphate replenishment mediated by Nir2 and Nir3 at endoplasmic reticulum-plasma membrane junctions. PMID: 25887399
Nir2 translocates from the Golgi complex to the plasma membrane in response to GF stimulation. PMID: 23897088
Results suggest a feedback mechanism that replenishes PM PIP2 during receptor-induced Ca(2+) signaling via the Ca(2+) effector E-Syt1 and the PITP Nir2 at ER-PM junctions. PMID: 24183667
Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. PMID: 12077336
A specific Thr residue in the Nir2 PI-transfer domain provides a regulatory site for targeting to lipid droplets. This may affect intracellular lipid trafficking & distribution & explain the dominant effect of the RdgB-T59E mutant on retinal degeneration. PMID: 12225667
Phosphorylation of Nir2 by Cdk1 facilitates its dissociation from the Golgi apparatus, and phospho-Nir2 is localized in the cleavage furrow and midbody during cytokinesis. PMID: 15125835
Nir2 is involved in maintaining a critical DAG pool in the Golgi apparatus by regulating its consumption via the CDP-choline pathway PMID: 15723057
RdgB homologs play a preemptive role in excluding endogenous and exogenous modified purine deoxyribonucleoside triphosphates (dTNPs) from incorporation into DNA. PMID: 17090528

Hide All

Subcellular Location

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet. Cleavage furrow. Midbody.

Protein Families

PtdIns transfer protein family, PI transfer class IIA subfamily

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 9003

OMIM: 608794

KEGG: hsa:9600

STRING: 9606.ENSP00000348772

UniGene: Hs.372295

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PITPNM1 Antibody

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Target Background