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PJA1 Antibody

Datasheet
Code CSB-PA018049GA01HU
Size $600
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Product Details

Uniprot No.
Q8NG27
Target Names
PJA1
Alternative Names
E3 ubiquitin-protein ligase Praja 1 antibody; E3 ubiquitin-protein ligase Praja-1 antibody; PJA1 antibody; PJA1_HUMAN antibody; PRAJA 1 antibody; Praja ring finger 1 antibody; Praja1 antibody; RING finger protein 70 antibody; RNF 70 antibody; RP23-414J22.4 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human PJA1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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PJA1 Proteins

Customer Reviews and Q&A

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Target Background

Function
Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting.
Gene References into Functions
  1. Data provide clues into novel aspects of Praja1 function. PMID: 21461837
  2. these results suggest a role for PRAJA1 in regulating the level of PRC2 by targeting its free subunits for Ub-mediated proteasomal degradation. PMID: 21513699
  3. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. PMID: 11959851
  4. Involved in protein ubiquitination in the brain. Candidate gene for X-linked mental retardation. PMID: 12036302
Tissue Specificity
Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex.
Database Links

HGNC: 16648

OMIM: 300420

KEGG: hsa:64219

STRING: 9606.ENSP00000355014

UniGene: Hs.522679

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