PLCH1 Antibody

Code CSB-PA018136GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
PLCH1
Alternative Names
1-phosphatidylinositol 4 antibody; 1-phosphatidylinositol-4 antibody; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1 antibody; 5-bisphosphate phosphodiesterase eta-1 antibody; DKFZp434C1372 antibody; KIAA1069 antibody; MGC117152 antibody; Phosphoinositide phospholipase C-eta-1 antibody; Phospholipase C-eta-1 antibody; Phospholipase C-like protein 3 antibody; PLC-eta-1 antibody; PLC-L3 antibody; PLCeta1 antibody; Plch1 antibody; PLCH1_HUMAN antibody; PLCL3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human PLCH1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
Gene References into Functions
  1. High fertilization (56.06%) and pregnancy (41.7%) rates accomplished in this study following ICSI-AOA indicated that expression profiles of PLCzeta, PAWP, and TR-KIT were low in globozoospermic individuals PMID: 27089467
  2. A molecular model of the PLCeta2 EF-hand domain, constructed based upon the structure of calmodulin, suggested both EF-loops may participate in Ca(2+) -binding. PMID: 24123053
  3. The PLCH1 rs181696 single-nucleotide polymorphism was strongly associated with an increased risk of squamous cell carcinoma. PMID: 22658813
  4. molecular cloning of PLC-eta1 and PLC-eta2 PMID: 15583837
  5. The identification of a novel PLC isoform in the brains of human and mouse, named PLC-eta, which contains the conserved pleckstrin homology domain, X and Y domains for catalytic activity and the C2 domain. PMID: 15702972

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Subcellular Location
Cytoplasm. Membrane.
Tissue Specificity
Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.
Database Links

HGNC: 29185

OMIM: 612835

KEGG: hsa:23007

STRING: 9606.ENSP00000345988

UniGene: Hs.567423

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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