PLD3 Antibody

Code CSB-PA018146LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018146LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA018146LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PLD3 Polyclonal antibody
Uniprot No.
Target Names
PLD3
Alternative Names
Choline phosphatase 3 antibody; HindIII K4L homolog antibody; HU K4 antibody; Hu-K4 antibody; HUK4 antibody; Phosphatidylcholine hydrolyzing phospholipase D3 antibody; Phosphatidylcholine-hydrolyzing phospholipase D3 antibody; Phospholipase D family; member 3 antibody; Phospholipase D3 antibody; PLD 3 antibody; PLD3 antibody; PLD3_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Phospholipase D3 protein (70-176AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PLD3 Antibody (Product code: CSB-PA018146LA01HU) is Non-conjugated. For PLD3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA018146LB01HU PLD3 Antibody, HRP conjugated ELISA
FITC CSB-PA018146LC01HU PLD3 Antibody, FITC conjugated
Biotin CSB-PA018146LD01HU PLD3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting.
Gene References into Functions
  1. Data show that phospholipase D3 (PLD3) functions in endosomal protein sorting and plays an important role in regulating amyloid precursor protein (APP) processing. PMID: 29368044
  2. PLD3 variant V232M was associated with Alzheimer's disease risk in overall sample sets. PMID: 26189833
  3. main findings of our this provide evidence that support the possible role of PLD3 common variants in influencing AD-related neuroimaging phenotypes. PMID: 26232066
  4. Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort PMID: 26411346
  5. one PLD3 variant (rs11667768) was associated with amyloid burden detected by CSF in normal individuals, suggesting the potential role of PLD3 in Abeta pathology PMID: 26402410
  6. The rare coding variant might not play an important role in AD risk in mainland China. PMID: 24866402
  7. genetic and functional data indicate that carriers of PLD3 coding variants have a twofold increased risk for late-onset Alzheimer's disease and that PLD3 influences APP processing PMID: 24336208
  8. PLD3 localizes to lysosomes PMID: 21752829
  9. PLD3 overexpression may inhibit Akt phosphorylation and further block the transduction of insulin signaling in C2C12 cells. PMID: 20112697
  10. Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies. PMID: 16580565
  11. receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner PMID: 19525236

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Involvement in disease
Genetic variants in PLD3 have been suggested to be associated with an increased risk for Alzheimer disease (PubMed:24336208, PubMed:25832409). Further studies, however, did not support PLD3 involvement in this disease (PubMed:25832408, PubMed:25832411, PubMed:25832413, PubMed:25832410, PubMed:26411346).
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Lysosome lumen. Early endosome membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Protein Families
Phospholipase D family
Tissue Specificity
Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum.
Database Links

HGNC: 17158

OMIM: 615698

KEGG: hsa:23646

STRING: 9606.ENSP00000348901

UniGene: Hs.257008

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