PLEKHA8 Antibody

Code CSB-PA856957LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: PLEKHA8 antibody at 0.8μg/ml + Mouse brain tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 59, 52, 50 kDa
    Observed band size: 59 kDa

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA856957LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA856957LA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PLEKHA8 Polyclonal antibody
Uniprot No. Q96JA3
Target Names PLEKHA8
Alternative Names FAPP-2 antibody; FAPP2 antibody; hFAPP2 antibody; MGC3358 antibody; PH domain-containing family A member 8 antibody; Phosphatidylinositol-four-phosphate adapter protein 2 antibody; Phosphoinositide binding specificmember 8 antibody; Phosphoinositol 4 phosphate adaptor protein 2 antibody; Phosphoinositol 4-phosphate adapter protein 2 antibody; PKHA8_HUMAN antibody; Pleckstrin homology domain containing A8 antibody; Pleckstrin homology domain containing family A (Phosphoinositide binding specific) member 8 antibody; Pleckstrin homology domain containing family A antibody; Pleckstrin homology domain-containing family A member 8 antibody; Plekha8 antibody; PLEKHA8 protein antibody; Serologically defined breast cancer antigen NY-BR-86 antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Pleckstrin homology domain-containing family A member 8 protein (1-300AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
Gene References into Functions
  1. Altogether, this study implies that hepatitis C virus coopts FAPP2 for virus genome replication via phosphatidylinositol 4-phosphate binding and glycosphingolipid transport to the hepatitis C virus replication complex. PMID: 25122779
  2. FAPP2 functions in both membrane trafficking and lipid metabolism in a fashion that integrates its activities in membrane trafficking and in lipid transfer. (Review) PMID: 22266015
  3. Data demonstrate FAPP2 is required for cilium formation in polarized MDCK cells. PMID: 17116893
  4. Data show that FAPP2 is present in tubules forming from the trans-Golgi in epithelial MDCK cells. PMID: 19940249
  5. FAPP2 plays a specific role in apical transport in MDCK cells. PMID: 16103222
  6. by coupling the synthesis of glycosphingolipids with their export to the cell surface, FAPP2 emerges as crucial in determining the lipid identity and composition of the plasma membrane PMID: 17687330
  7. These data demonstrate a previously unknown role for FAPP2 in conferring resistance to apoptosis and indicate that FAPP2 may be a target for cancer therapy. PMID: 19341712

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Subcellular Location Golgi apparatus, trans-Golgi network membrane, Membrane, Peripheral membrane protein
Tissue Specificity Expressed in kidney cell lines.
Database Links

HGNC: 30037

OMIM: 608639

KEGG: hsa:84725

STRING: 9606.ENSP00000397947

UniGene: Hs.233495

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