PLEKHA8 Antibody, Biotin conjugated

Code CSB-PA856957LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PLEKHA8 Polyclonal antibody
Uniprot No.
Target Names
PLEKHA8
Alternative Names
FAPP-2 antibody; FAPP2 antibody; hFAPP2 antibody; MGC3358 antibody; PH domain-containing family A member 8 antibody; Phosphatidylinositol-four-phosphate adapter protein 2 antibody; Phosphoinositide binding specificmember 8 antibody; Phosphoinositol 4 phosphate adaptor protein 2 antibody; Phosphoinositol 4-phosphate adapter protein 2 antibody; PKHA8_HUMAN antibody; Pleckstrin homology domain containing A8 antibody; Pleckstrin homology domain containing family A (Phosphoinositide binding specific) member 8 antibody; Pleckstrin homology domain containing family A antibody; Pleckstrin homology domain-containing family A member 8 antibody; Plekha8 antibody; PLEKHA8 protein antibody; Serologically defined breast cancer antigen NY-BR-86 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pleckstrin homology domain-containing family A member 8 protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
Gene References into Functions
  1. Altogether, this study implies that hepatitis C virus coopts FAPP2 for virus genome replication via phosphatidylinositol 4-phosphate binding and glycosphingolipid transport to the hepatitis C virus replication complex. PMID: 25122779
  2. FAPP2 functions in both membrane trafficking and lipid metabolism in a fashion that integrates its activities in membrane trafficking and in lipid transfer. (Review) PMID: 22266015
  3. Data demonstrate FAPP2 is required for cilium formation in polarized MDCK cells. PMID: 17116893
  4. Data show that FAPP2 is present in tubules forming from the trans-Golgi in epithelial MDCK cells. PMID: 19940249
  5. FAPP2 plays a specific role in apical transport in MDCK cells. PMID: 16103222
  6. by coupling the synthesis of glycosphingolipids with their export to the cell surface, FAPP2 emerges as crucial in determining the lipid identity and composition of the plasma membrane PMID: 17687330
  7. These data demonstrate a previously unknown role for FAPP2 in conferring resistance to apoptosis and indicate that FAPP2 may be a target for cancer therapy. PMID: 19341712

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Subcellular Location
Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein.
Tissue Specificity
Expressed in kidney cell lines.
Database Links

HGNC: 30037

OMIM: 608639

KEGG: hsa:84725

STRING: 9606.ENSP00000397947

UniGene: Hs.233495

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