PLEKHF2 Antibody

Datasheet

Code	CSB-PA884492ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA884492ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PLEKHF2 Polyclonal antibody

Uniprot No.

Q9H8W4

Target Names

PLEKHF2

Alternative Names

110070J07Rik antibody; AA673237 antibody; FLJ13187 antibody; PH and FYVE domain containing protein 2 antibody; PH and FYVE domain-containing protein 2 antibody; PH domain containing family F member 2 antibody; PH domain-containing family F member 2 antibody; Phafin 2 antibody; Phafin-2 antibody; PHAFIN2 antibody; PKHF2_HUMAN antibody; pleckstrin homology domain containing, family F (with FYVE domain) member 2 antibody; pleckstrin homology domain containing, family F (with FYVE domain) member2 antibody; Pleckstrin homology domain-containing family F member 2 antibody; Plekhf2 antibody; ZFYVE18 antibody; Zinc finger FYVE domain containing protein 18 antibody; Zinc finger FYVE domain-containing protein 18 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pleckstrin homology domain-containing family F member 2 protein (1-249AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.

Gene References into Functions

PtdIns(3)P binding to Phafin2 occurs with high affinity, triggering minor conformational changes in the protein. Taken together, these studies represent a platform for establishing the structural basis of Phafin2 molecular interactions and the role of the two potentially redundant PtdIns(3)P-binding domains of the protein in endomembrane compartments. PMID: 28152563
These findings establish that lysosomal accumulation of Akt and Phafin2 is a critical step in the induction of autophagy via an interaction with phosphatidylinositol 3 phosphate. PMID: 24416124
Phafin2 controls EGFR trafficking through early endosomes by facilitating endosome fusion in concert with EEA1. PMID: 22816767
These results provide a vivid example that an endosome modulator, such as Phafin2, may control the cells' responses to the extracellular cues. PMID: 19995552
Results demonstrate that EAPF/Phafin-2 facilitates TNF-alpha-induced cellular apoptosis through an ER-mitochondrial apoptotic pathway. PMID: 18288467

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Subcellular Location

Early endosome membrane; Peripheral membrane protein. Endoplasmic reticulum.

Tissue Specificity

Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.

Database Links

HGNC: 20757

OMIM: 615208

KEGG: hsa:79666

STRING: 9606.ENSP00000322373

UniGene: Hs.29724

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Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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