PLXNB2 Antibody

Datasheet

Code	CSB-PA018223LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: A549 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate All lanes: PLXNB2 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 206 kDa Observed band size: 206 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PLXNB2 Polyclonal antibody

Uniprot No.

O15031

Target Names

PLXNB2

Alternative Names

PLXNB2 antibody; KIAA0315 antibody; Plexin-B2 antibody; MM1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Inhibitor of nuclear factor kappa-B kinase-interacting protein (1458-1673AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PLXNB2 Antibody (Product code: CSB-PA018223LA01HU) is Non-conjugated. For PLXNB2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA018223LB01HU	PLXNB2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018223LC01HU	PLXNB2 Antibody, FITC conjugated
Biotin	CSB-PA018223LD01HU	PLXNB2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Antigen Affinity purified & Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42.

Gene References into Functions

Knocking down of PLXNB2 with PLXNB2 siRNA results in repressed ovarian cancer cell proliferation and invasion, and decreased phosphorylation of AKT and ERK1/2 PMID: 30054097
Study shows that plexin-B2 (PLXNB2) is the functional receptor for ANG in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells. PMID: 29100074
Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins shows lack of binding specificity. PMID: 29040270
plexin-B2 is a downstream target for Rnd3, which contributes to its cellular function. PMID: 27656111
Plexin-B2 promotes glioma invasion and vascularization PMID: 25762646
In endometrial luminal epithelium, cadherin 6, desmoglein 2 and plexin b2 were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity. PMID: 25237006
High PLEXIN B2 expression is associated with high-grade gliomas. PMID: 24158112
Plexin B2 associates directly with two members of a recently identified family of Dbl homology/pleckstrin homology containing guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and Leukemia-associated Rho GEF (LARG). PMID: 12183458
cleavage by proprotein convertases is a novel regulatory step for semaphorin receptors localized at the cell surface. PMID: 12533544

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Plexin family

Database Links

HGNC: 9104

OMIM: 604293

KEGG: hsa:23654

STRING: 9606.ENSP00000352288

UniGene: Hs.3989

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Service

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Protein Service

Gene Synthesis Service

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SEMA4D/CD100: As an Important Immunoregulator to Improve Immunotherapy Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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