PMPCB Antibody

Datasheet

Code	CSB-PA280859
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA280859(PMPCB Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA280859(PMPCB Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O75439

Target Names

PMPCB

Alternative Names

Beta MPP antibody; Beta-MPP antibody; BetaMPP antibody; Mitochondrial processing peptidase subunit beta antibody; Mitochondrial-processing peptidase subunit beta antibody; MPP11 antibody; MPPB antibody; MPPB_HUMAN antibody; MPPP52 antibody; P 52 antibody; P-52 antibody; P52 antibody; Peptidase mitichondrial processing beta antibody; PMPCB antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human PMPCB

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis.

Gene References into Functions

biallelic mutations in PMPCB cause defects in MPP proteolytic activity leading to dysregulation of iron-sulfur cluster biogenesis and triggering a complex neurological phenotype of neurodegeneration in early childhood. PMID: 29576218
OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase. PMID: 24903103
These results highlight a new role for MPP in PINK1 import and mitochondrial quality control via the PINK1-Parkin pathway. PMID: 22354088
maintained expression and even up-regulation of some (PNPT1, PMPCB, HMMR/RHAMM, BSG and ERCC1) tumor associated antigens in CD40-activated leukemic cells. PMID: 19580345

Subcellular Location

Mitochondrion matrix.

Protein Families

Peptidase M16 family

Database Links

HGNC: 9119

OMIM: 603131

KEGG: hsa:9512

STRING: 9606.ENSP00000249269

UniGene: Hs.184211

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Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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