POGLUT1 Antibody

Code CSB-PA818754LA01HU
Size US$299
Image
  • Western Blot
    Positive WB detected in: HepG2 whole cell lysate, PC-3 whole cell lysate, K562 whole cell lysate, 293 whole cell lysate
    All lanes: POGLUT1 antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 47 kDa
    Observed band size: 47 kDa

  • IHC image of CSB-PA818754LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) POGLUT1 Polyclonal antibody
Uniprot No. Q8NBL1
Target Names POGLUT1
Alternative Names C3orf9 antibody; CAP10 like 46 kDa protein antibody; CAP10 like protein, 46 kDa antibody; CAP10-like 46 kDa protein antibody; CLP46 antibody; hCLP46 antibody; hRumi antibody; KDELC family like 1 antibody; KDELCL1 antibody; KTEL (Lys Tyr Glu Leu) containing 1 antibody; KTEL motif containing protein 1 antibody; KTEL motif-containing protein 1 antibody; KTEL1 antibody; KTELC1 antibody; MDS010 antibody; MDSRP antibody; Myelodysplastic syndromes relative protein antibody; O-glucosyltransferase rumi homolog antibody; PGLT1_HUMAN antibody; Poglut1 antibody; protein O glucosyltransferase 1 antibody; Protein O-glucosyltransferase 1 antibody; Protein O-xylosyltransferase antibody; Rumi antibody; x 010 protein antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Protein O-glucosyltransferase 1 protein (132-392AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:200-1:500
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C
Gene References into Functions
  1. Here we report the generation and characterization of an iPSC line (CSCRMi001-A) from a LGMD-2Z patient with missense mutation in POGLUT1 which can be used for in vitro disease modeling. PMID: 29034878
  2. The data suggest that hCLP46(human CAP10-like protein 46 kDa) overexpression in colorectal cancer is associated with higher tumor-node-metastasis stage, lymph node metastasis, and shorter survival time. PMID: 28481732
  3. These findings expand the spectrum of mutations in POGLUT1 and confirm POGLUT1 as the third candidate gene, along with KRT5 and POFUT1, to consider in diagnosis of GGD/DDD. PMID: 27479915
  4. These data suggest that a key pathomechanism for this novel form of muscular dystrophy with POGLUT1 mutation is Notch-dependent loss of satellite cells. PMID: 27807076
  5. hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation PMID: 26058784
  6. miR-134 inhibited human endometrial cancer stem cells proliferation and migration by targeting protein O-glucosyltransferase 1 (POGLUT1) expression PMID: 25528443
  7. Mutations in POFUT1, which encodes protein O-fucosyltransferase 1, were reported to be responsible for Dowling-Degos disease. PMID: 24387993
  8. overexpression of hCLP46 inhibited proliferation of 293TRexs and was correlated with increases in cyclin dependent kinase inhibitors p21 and p27, whereas reduced hCLP46 expression moderately increased cell proliferation. PMID: 23692084
  9. lack of hCLP46 results in impaired ligand induced Notch activation in mammalian cell, and hCLP46 regulates the proliferation of U937 cell through CDKI-RB signaling pathway, which may be important for the pathogenesis of leukemia. PMID: 21458412
  10. CLP46 was overexpressed in AML, T-ALL, and leukemic cell lines. Considering that CLP46 has the capability of modifying the Notch pathway, our finding adds weight to the possible importance of Notch signaling in the pathogenesis of AML and T-ALL. PMID: 20143914
  11. Altered C3ORF9 expression in myelodysplastic syndrome was possibly due to different gene regulation in these patients and/or to the increased CD34+ cells. PMID: 19822096

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Involvement in disease Dowling-Degos disease 4 (DDD4); Limb-girdle muscular dystrophy 2Z (LGMD2Z)
Subcellular Location Endoplasmic reticulum lumen
Protein Families Glycosyltransferase 90 family
Tissue Specificity Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. E
Database Links

HGNC: 22954

OMIM: 615618

KEGG: hsa:56983

STRING: 9606.ENSP00000295588

UniGene: Hs.231750

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