PPP2R5A Antibody

Code CSB-PA171127
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Product Details

Uniprot No. Q15172
Target Names PPP2R5A
Alternative Names 2A5A_HUMAN antibody; B56A antibody; MGC131915 antibody; PP2A B subunit B' alpha isoform antibody; PP2A B subunit B56 alpha isoform antibody; PP2A B subunit isoform B''-alpha antibody; PP2A B subunit isoform B56-alpha antibody; PP2A B subunit isoform PR61-alpha antibody; PP2A B subunit isoform R5-alpha antibody; PP2A B subunit PR61 alpha isoform antibody; PP2A B subunit R5 alpha isoform antibody; PPP2R5A antibody; PR61A antibody; PR61alpha antibody; Protein phosphatase 2 regulatory subunit B (B56) alpha isoform antibody; Protein phosphatase 2 regulatory subunit B' alpha antibody; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of Human PP2A-B56-α.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:5000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Gene References into Functions
  1. Studies indicate protein phosphatase 2, regulatory subunit B', alpha isoform protein (PPP2R5A) plays an important role in many cellular activities. PMID: 29175459
  2. Overexpression of miR-218 led to inhibition of PPP2R5A expression, whereas knockdown of miR-218 increased PPP2R5A levels. Introduction of PPP2R5A abrogated miR218-mediated cell survival and drug resistance. PMID: 28849187
  3. A mitotic phosphorylation site on Cdc20, known to be a substrate of PP2A(B56), modulates APC/C(Cdc20) assembly. PMID: 28404789
  4. Results report that BubR1 and RepoMan bind directly to PP2A-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser residue enhances binding. RepoMan and BubR1 bind B56 using both hydrophobic and electrostatic interactions. PMID: 27998540
  5. cyclin E is specifically dephosphorylated at S384 by the PP2A-B56 phosphatase, thereby uncoupling cyclin E degradation from cyclin E-CDK2 activity PMID: 28137908
  6. structure of the PP2A B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A to specific targets. PMID: 27350047
  7. results suggest that PKCalpha can modify PP2A activity by phosphorylation of B56alpha at Ser(41). This interplay between PKCalpha and PP2A represents a new mechanism to regulate important cellular functions like cellular Ca(2+) homeostasis. PMID: 24225947
  8. PP2A regulatory subunit Balpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7. PMID: 23955003
  9. Following TGF-beta1 treatment, recruitment of PP2A-Balpha by TbetaRI increased in benign cells, but not in malignant cells. Inhibition of PP2A in benign cells resulted in an increase in ERK activation and in TGF-beta1 auto-induction after TGF-beta1 treatment. PMID: 21030067
  10. reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 and B56-containing PP2As, has an important impact on the stability of Gli transcription factors and Hh signaling. PMID: 21878643
  11. Reveal that PPP2R5A, an essential tumour suppressor, tunes the balance of phosphorylation to promote chromosome-spindle interactions during cell division. PMID: 21874008
  12. The PP2A-B'alpha holoenzyme appears to function as an important endogenous regulator of SK1. PMID: 21075214
  13. B56alpha has a role in nuclear export of the catalytic subunit of PP2A PMID: 20378546
  14. The B'alpha subunit of protein phosphatase 2A (PP 2A) as a CHK2 binding partner shows that their interaction is modulated by DNA damage. PMID: 20160490
  15. PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells. PMID: 18957415
  16. The B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated. PMID: 18981217
  17. these data indicate that the B subunits alpha and delta are essential for the interaction of PP2A with CaMKIV. PMID: 19538941

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Subcellular Location Cytoplasm. Nucleus. Chromosome, centromere.
Protein Families Phosphatase 2A regulatory subunit B56 family
Tissue Specificity Widely expressed with the highest expression in heart and skeletal muscle.
Database Links

HGNC: 9309

OMIM: 601643

KEGG: hsa:5525

STRING: 9606.ENSP00000261461

UniGene: Hs.744012

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