PRICKLE3 Antibody, HRP conjugated

Datasheet
Code CSB-PA018678PB01HU
Size US$299
Uniprot No. O43900
Immunogen Recombinant Human Prickle-like protein 3 protein (9-24AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6), PRICKLE3, LMO6
Immunogen Species Human
Protocols ELISA Protocol
Research Area Cell Biology
Target Names PRICKLE3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).
Subcellular Location Cytoplasm, Cell membrane, Peripheral membrane protein, Cytoplasmic side
Protein Families Prickle / espinas / testin family
Tissue Specificity Widely expressed.
Database Links

HGNC: 6645

OMIM: 300111

KEGG: hsa:4007

STRING: 9606.ENSP00000365494

UniGene: Hs.732712

Pathway Wnt signaling pathway

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