PRKAA2 Antibody

Datasheet
Code CSB-PA117532
Size US$299
Uniprot No. P54646
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA117532(PRKAA2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA117532(PRKAA2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
Immunogen Fusion protein of Human PRKAA2
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC;ELISA:1:2000-1:5000,IHC:1:25-1:100
Relevance The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias protein kinase, AMP-activated, alpha 2 catalytic subunit
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Target Names PRKAA2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes
Subcellular Location Cytoplasm, Nucleus
Protein Families Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Database Links

HGNC: 9377

OMIM: 600497

KEGG: hsa:5563

STRING: 9606.ENSP00000360290

UniGene: Hs.437039

Pathway mTOR signaling pathway
PI3K-Akt signaling pathway
Autophagy
MAPK Erk pathway
Adipocytokine signaling pathway
AMPK signaling
Apelin signaling pathway
FoxO signaling pathway
Glucagon signaling pathway
Insulin signaling pathway
Myocardial Fatty Acid Metabolism

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