PRPF4 Antibody

Datasheet

Code	CSB-PA018768GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O43172

Target Names

PRPF4

Alternative Names

hPrp4 antibody; HPRP4P antibody; PRP4 antibody; PRP4 homolog antibody; PRP4 pre mRNA processing factor 4 homolog (yeast) antibody; PRP4/STK/WD splicing factor antibody; PRP4_HUMAN antibody; Prp4p antibody; PRPF4 antibody; RP70 antibody; SNRNP60 antibody; U4/U6 small nuclear ribonucleoprotein Prp4 antibody; U4/U6 snRNP 60 kDa protein antibody; WD splicing factor Prp4 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human PRPF4

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

Gene References into Functions

The p.R192H variant of PRPF4 represents a functional null allele which compromises the function of the tri-snRNP, reinforcing the notion that this spliceosomal particle is of crucial importance in the physiology of the retina. PMID: 25383878
PRPF4 missense mutations is associated with autosomal dominant retinitis pigmentosa. PMID: 24419317
the requirement of enzymatic activity of PRP4 in regulating cancer cell growth and identified an array of potential novel substrates through orthogonal proteomics approaches PMID: 24003220
interaction between Hprp3p and Hprp4p PMID: 11971898
PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores. PMID: 17998396
PRP-4 belongs to the serine/threonine protein kinase family, plays a role in pre-mRNA splicing and cell mitosis, and interacts with CLK1 PMID: 18687998

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Involvement in disease

Retinitis pigmentosa 70 (RP70)

Subcellular Location

Nucleus. Nucleus speckle.

Database Links

HGNC: 17349

OMIM: 607795

KEGG: hsa:9128

STRING: 9606.ENSP00000363313

UniGene: Hs.744014

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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