PRPF4 Antibody

Datasheet

Code	CSB-PA018768ESR2HU
Size	US$166
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Image	Western blot All lanes: PRPF4 antibody at 3.89 μg/ml Lane 1: Jurkat whole cell lysate Lane 2: Hela whole cell lysate Lane 3: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 58 kDa Observed band size: 58 kDa Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA018768ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018768ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PRPF4 Polyclonal antibody

Uniprot No.

O43172

Target Names

PRPF4

Alternative Names

hPrp4 antibody; HPRP4P antibody; PRP4 antibody; PRP4 homolog antibody; PRP4 pre mRNA processing factor 4 homolog (yeast) antibody; PRP4/STK/WD splicing factor antibody; PRP4_HUMAN antibody; Prp4p antibody; PRPF4 antibody; RP70 antibody; SNRNP60 antibody; U4/U6 small nuclear ribonucleoprotein Prp4 antibody; U4/U6 snRNP 60 kDa protein antibody; WD splicing factor Prp4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human U4/U6 small nuclear ribonucleoprotein Prp4 protein (1-260AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

Gene References into Functions

The p.R192H variant of PRPF4 represents a functional null allele which compromises the function of the tri-snRNP, reinforcing the notion that this spliceosomal particle is of crucial importance in the physiology of the retina. PMID: 25383878
PRPF4 missense mutations is associated with autosomal dominant retinitis pigmentosa. PMID: 24419317
the requirement of enzymatic activity of PRP4 in regulating cancer cell growth and identified an array of potential novel substrates through orthogonal proteomics approaches PMID: 24003220
interaction between Hprp3p and Hprp4p PMID: 11971898
PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores. PMID: 17998396
PRP-4 belongs to the serine/threonine protein kinase family, plays a role in pre-mRNA splicing and cell mitosis, and interacts with CLK1 PMID: 18687998

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Involvement in disease

Retinitis pigmentosa 70 (RP70)

Subcellular Location

Nucleus. Nucleus speckle.

Database Links

HGNC: 17349

OMIM: 607795

KEGG: hsa:9128

STRING: 9606.ENSP00000363313

UniGene: Hs.744014

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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