PRR11 Antibody

Datasheet

Code	CSB-PA836225LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA836225LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA836225LA01HU at dilution of 1:100 Immunofluorescent analysis of PC-3 cells using CSB-PA836225LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: Mouse heart tissue All lanes: PRR11 antibody at 3.2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 41 kDa Observed band size: 41 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PRR11 Polyclonal antibody

Uniprot No.

Q96HE9

Target Names

PRR11

Alternative Names

FLJ11029 antibody; Homo sapiens proline rich 11 antibody; Proline rich protein 11 antibody; Proline-rich protein 11 antibody; PRR 11 antibody; Prr11 antibody; PRR11_HUMAN antibody; transcription repressor of MHCII antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Proline-rich protein 11 protein (1-360AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PRR11 Antibody (Product code: CSB-PA836225LA01HU) is Non-conjugated. For PRR11 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA836225LB01HU	PRR11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836225LC01HU	PRR11 Antibody, FITC conjugated
Biotin	CSB-PA836225LD01HU	PRR11 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The PRR11 antibody (CSB-PA836225LA01HU) is produced in the rabbit with a peptide corresponding to amino acids 1-360 of the human PRR11 immunized. This polyclonal antibody occurs as an unconjugated IgG. Its purity is 95%⁺ using protein G purified. It is reactive with human and mouse samples. The PRR11 protein, a newly identified oncogene related to a poor prognosis in several human cancers, exerts multiple biological effects, including the modulation of cell cycle and promotion of cellular migration and invasion. This anti-PRR11 antibody has been quality-verified in ELISA, WB, IHC, and IF applications.

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Target Background

Function

Plays a critical role in cell cycle progression.

Gene References into Functions

PRR11 plays an oncogenic role in hepatocellular carcinoma (HCC) progression, through activating the Wnt/beta-catenin signaling pathway, and may represent a valuable prognostic marker and therapeutic target for HCC. PMID: 30248355
PRR11 positively regulated cell proliferation-related proteins, including c-myc and cyclin D1, and increased and decreased the expression of matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 and PRR11 expression was mediated by the phosphoinositide 3-kinase/AKT/beta-catenin signaling pathway. PMID: 30165366
these findings further illustrate the suppressive role of miR-195 in prostate cancer (PCa), and indicate a novel role of PRR11 in PCa. Importantly, the newly identified miR-195/PRR11 axis may aid with identifying potential therapeutic targets in PCa. PMID: 29393495
PRR11 regulated self-renewal and tumorigenicity of gastric cancer stem cells through MAPK signaling, and could be used as a therapeutic target for gastric cancer. PMID: 30007956
these findings indicated that miR-144-3p induced cell cycle arrest and apoptosis in pancreatic cancer by targeting PRR11. PMID: 28574724
p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID: 28257042
Microarray analysis revealed that several genes involved in cell proliferation, cell adhesion, and cell migration were altered in PRR11-knockout cells. PMID: 25971332
PRR11 may be widely activated in human gastric cancer. PMID: 26252227
Targeted depletion of PRR11 caused a dramatic cell cycle arrest followed by massive apoptotic cell death, and eventually resulted in a significant decrease in growth and viability in lung cancer cell lines. PMID: 25973065
PRR11-SKA2 bidirectional transcription unit, which is a novel direct target of NF-Y, is essential for the accelerated proliferation and motility of lung cancer cells PMID: 26162986
Overexpression of PRR11 inhibits cell proliferation and induces premature chromatin condensation. PMID: 25666944
our results strongly demonstrated that this newly identified gene, PRR11, had a critical role in both cell cycle progression and tumorigenesis, and might serve as a novel potential target in the diagnosis and/or treatment of human lung cancer. PMID: 23246489
the apparent occurrence of an unusual TG 3' splice site in intron 10 is discussed PMID: 17672918

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Subcellular Location

Cytoplasm. Nucleus.

Tissue Specificity

Ubiquitously expressed.

Database Links

HGNC: 25619

OMIM: 615920

KEGG: hsa:55771

STRING: 9606.ENSP00000262293

UniGene: Hs.631750

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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