PTPRF Antibody

Code CSB-PA019053LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA019053LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA019053LA01HU at dilution of 1:100

  • Immunofluorescence staining of HepG2 cells with CSB-PA019053LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PTPRF Polyclonal antibody
Uniprot No.
Target Names
PTPRF
Alternative Names
FLJ43335 antibody; FLJ45062 antibody; FLJ45567 antibody; LAR antibody; LAR protein antibody; LARFN5C antibody; LARS antibody; LCA homolog antibody; Leukocyte antigen related (LAR) PTP receptor antibody; Leukocyte antigen related antibody; Leukocyte antigen related PTP receptor antibody; Leukocyte antigen related tyrosine phosphatase antibody; Leukocyte common antigen related antibody; Protein Tyrosine Phosphatase Receptor Type F antibody; Protein tyrosine phosphatase receptor type F polypeptide antibody; Ptprf antibody; PTPRF protein antibody; PTPRF_HUMAN antibody; Receptor linked protein tyrosine phosphatase LAR antibody; Receptor type tyrosine protein phosphatase F antibody; Receptor type tyrosine protein phosphatase F precursor antibody; Receptor-type tyrosine-protein phosphatase F antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Receptor-type tyrosine-protein phosphatase F protein (688-970AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PTPRF Antibody (Product code: CSB-PA019053LA01HU) is Non-conjugated. For PTPRF Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA019053LB01HU PTPRF Antibody, HRP conjugated ELISA
FITC CSB-PA019053LC01HU PTPRF Antibody, FITC conjugated
Biotin CSB-PA019053LD01HU PTPRF Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Gene References into Functions
  1. transferred nuclear Overhauser effects (trNOEs) have been employed in the docking program HADDOCK to generate models for the LAR-fondaparinux complex. These models are further analyzed by postprocessing energetic analysis to identify key binding interactions. PMID: 29570275
  2. PTPRF may have value as a predictive marker to identify which patients can obtain the greatest benefit from erlotinib in the post-first-line setting. PMID: 26291013
  3. Homozygous truncating PTPRF mutation causes athelia. PMID: 24781087
  4. PTPRF is down-regulated in hepatocellular carcinoma-facilitated tumor development. PMID: 24470239
  5. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. PMID: 23986473
  6. LAR functions as a negative regulator of adipogenesis. PMID: 19910497
  7. regulation of expression by cell density through functional E-cadherin complexes PMID: 12095414
  8. LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation PMID: 12496362
  9. LAR as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin PMID: 15896785
  10. Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways. PMID: 16478662
  11. Regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996
  12. LAR and Src are identified as Death-associated protein kinase (DAPK) regulators through their reciprocal modification of DAPK Y491/492 residues and establishes a functional link of this DAPK-regulatory circuit to tumor progression. PMID: 17803936

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Involvement in disease
Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2)
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Protein-tyrosine phosphatase family, Receptor class 2A subfamily
Database Links

HGNC: 9670

OMIM: 179590

KEGG: hsa:5792

STRING: 9606.ENSP00000353030

UniGene: Hs.272062

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