PURA Antibody

1. Three genes in our epilepsy cohort (COQ4, DNM1, and PURA), accounting for 14% (3/21) of all novel genetic etiologies identified in patients with epilepsy, were subsequently confirmed in independent publications. PMID: 26795593
2. PURA may be a potential target of miR-144 and observed downregulation of PURA may be caused by increased expression of miR-144. The other predicted target of miR-144 SPRED1, was found to be downregulated in 69 per cent EC tissues as compared to matched distant non-malignant tissues. PMID: 27748283
3. The results of this study emphasizes the importance of stress granules in ALS pathogenesis and identifies Pur-alpha as a novel regulator of cytoplasmic stress granules dynamics. PMID: 26728149
4. These findings provide definitive evidence for the role of PURA in causing a variable syndrome of neurodevelopmental delay, learning disability, neonatal hypotonia, feeding difficulties, abnormal movements and epilepsy in humans PMID: 25342064
5. Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome. PMID: 25439098
6. Data show that protein PURalpha is specifically involved in the transcriptional activation of the secondary promoter and may exert its function by forming a complex with E2F-1 and RNA polymerase II. PMID: 24819879
7. Suggest dynamic interplay between transcriptional activators Pur-alpha/Pur-beta and repressors in regulating SMalphaA gene output during myofibroblast differentiation. PMID: 24446247
8. This study showed that Pur-alpha showed inadequate expression in monocytes, and the translation of Pur-alpha mRNA was repressed by cell-expressed microRNA. PMID: 22835829
9. The study identifies three functionally distinct PURA promoters and show that these are utilized differentially in human cell types and that they respond differently to cytomegalovirus infection. PMID: 21062477
10. The ability of Puralpha to activate the CD11c gene promoter increases in differentiating U937 monocytic cells. PMID: 11937543
11. acts together with hnRNP-K to repress the transcriptional activity of the CD43 gene promoter during lymphocyte activation PMID: 12411317
12. results show that PUR proteins are capable of binding to alpha-MHC mRNA and attenuate its translational efficiency; also show robust expression of PUR proteins in failing hearts where alpha-MHC mRNA levels are suppressed PMID: 12933792
13. The N-terminal 72 amino acids of Pura were involved in E2F-1 binding, inhibition of promoter activation by E2F-1 and reversal of E2F-mediated growth inhibition. PMID: 15517862
14. Puralpha has been shown to colocalize with cyclin A/Cdk2 and to coimmunoprecipitate with cyclin A during S-phase and we show that this interaction is mediated by a specific affinity of Puralpha for Cdk2. PMID: 15707957
15. Hypoxia induces a coordinated up-regulation in beta2 integrin expression that is dependent upon transcriptional mechanisms mediated by HIF-1 and Pur alpha. PMID: 17641060
16. the partnership of Puralpha with Rev is beneficial for Rev-mediated expression of the HIV-1 genome. PMID: 17722108
17. that the recruitment of YB1, PURalpha, and H1.2 to the p53 target gene Bax is required for repression of p53-induced transcription. PMID: 18258596
18. Stably overexpressing PURalpha in PC3 and DU145 cells negatively regulates cell proliferation, resulting in decreases in PCNA expression PMID: 18386260
19. A transcriptional repressor complex that binds a specific sequence (repressor element) in the androgen recptor gene 5'-untranslated region in prostate cancer contains Pur alpha. PMID: 18413735
20. Pur-alpha protein is associated with Alzheimer's disease. PMID: 18780968
21. Effects of the DNA damage-inducing cancer chemotherapeutic agent cisplatin on mouse embryo fibroblasts (MEFs) from PURA negative knockout mice. PMID: 18927497
22. Regulation of PURalpha expression in prostate cancer cells may serve as a therapeutic target for hormone refractory prostate cancer. PMID: 19267365

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HGNC: 9701

OMIM: 600473

KEGG: hsa:5813

STRING: 9606.ENSP00000332706

UniGene: Hs.443121