Pcsk1 Antibody

Datasheet

Code	CSB-PA017640LA01RA
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Rattus norvegicus (Rat) Pcsk1 Polyclonal antibody

Uniprot No.

P28840

Target Names

Pcsk1

Alternative Names

Pcsk1 antibody; Bdp antibody; Nec-1 antibody; Nec1Neuroendocrine convertase 1 antibody; NEC 1 antibody; EC 3.4.21.93 antibody; Prohormone convertase 1 antibody; Proprotein convertase 1 antibody; PC1 antibody

Raised in

Rabbit

Species Reactivity

Rat

Immunogen

Recombinant Rat Neuroendocrine convertase 1 protein (111-752AA)

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

The Pcsk1 Antibody (Product code: CSB-PA017640LA01RA) is Non-conjugated. For Pcsk1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA017640LB01RA	Pcsk1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017640LC01RA	Pcsk1 Antibody, FITC conjugated
Biotin	CSB-PA017640LD01RA	Pcsk1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.

Gene References into Functions

macrophages from PC1/3 KO mice and rat PC1/3-KD NR8383 macrophages secreted more pro-inflammatory cytokines such as TNF-alpha, IL6, IL1alpha and CXCL2. PMID: 26778167
PC1/3 as an important regulator of vesicle trafficking and secretion in macrophages. PMID: 23637853
Chronic ethanol exposure decreases prohormone convertase (pc1/3) immunoreactivity in brain. PMID: 23050949
catalytic and P domains contribute to the folding and thermodynamic stability of the convertases through reciprocal hydrophobic interactions (prohormone convertase 3 [pc3/pc1]) PMID: 12721373
The prohormone convertase (PC) enzyme PC1 together with PC2 and PC5 may represent a redundant system to ensure production of biologically active cholecystokinin in rat brain. PMID: 14608596
proGHRH is initially cleave by furin at preproGHRH29-30, followed by a second cleavage at preproGHRH74 primarily by PC1 to generate GHRH and GHRH-RP peptides, respectively. PMID: 15146101
Leptin regulates hypothalamic PC1 expression and requires prohormone processing into mature peptides. PMID: 15286802
Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides PMID: 16204236
the prohormone convertase cleavage site within the alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway PMID: 16221685
The observed decrease in CCK seen with these RNAi treatments further supports a role for PC1 in CCK processing in these cells PMID: 16274843
Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132. PMID: 16384863
These data indicate that the transmembrane domain of PC3 plays a key role in sorting the enzyme to the regulated secretory pathway. PMID: 17240044
Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. PMID: 18784614

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Subcellular Location

Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.

Protein Families

Peptidase S8 family, Furin subfamily

Database Links

KEGG: rno:25204

STRING: 10116.ENSRNOP00000015185

UniGene: Rn.11384

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