Pdk3 Antibody, HRP conjugated

Code CSB-PA852852LB01MO
Size US$166
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Pdk3 Polyclonal antibody
Uniprot No.
Target Names
Pdk3
Alternative Names
Pdk3 antibody; [Pyruvate dehydrogenase antibody; acetyl-transferring)] kinase isozyme 3 antibody; mitochondrial antibody; EC 2.7.11.2 antibody; Pyruvate dehydrogenase kinase isoform 3 antibody
Raised in
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant Mouse [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial protein (131-362AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.
Gene References into Functions
  1. demonstrate that the increased PDK3 activity in patient fibroblasts (PDK3(R158H)) leads to the attenuation of PDC through hyper-phosphorylation of E1 at selected serine residues PMID: 27388934
Subcellular Location
Mitochondrion matrix.
Protein Families
PDK/BCKDK protein kinase family
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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