Prothoracicotropic hormone Antibody

Code CSB-PA324609LA01BTT
Size US$166
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Product Details

Uniprot No.
Alternative Names
antibody; Prothoracicotropic hormone antibody; PTTH) [Cleaved into: P2K; P6K; Prothoracicotropic hormone] antibody
Raised in
Rabbit
Species Reactivity
Bombyx mori
Immunogen
Recombinant Bombyx mori Prothoracicotropic hormone protein (116-224AA)
Immunogen Species
BOMMO(Silk moth)
Conjugate
Non-conjugated

The Prothoracicotropic hormone Antibody (Product code: CSB-PA324609LA01BTT) is Non-conjugated. For Prothoracicotropic hormone Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA324609LB01BTT Prothoracicotropic hormone Antibody, HRP conjugated ELISA
FITC CSB-PA324609LC01BTT Prothoracicotropic hormone Antibody, FITC conjugated
Biotin CSB-PA324609LD01BTT Prothoracicotropic hormone Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
PTTH is a brain secretory polypeptide of insects which stimulates the prothoracic glands to produce and release ecdysone, the steroid essential to insect development.; Peptides P2K and P6K are presumed to be cleaved post-translationally and may play some unknown physiologically or developmentally important functions.
Gene References into Functions
  1. HR38 is a prothoracicotropic hormone(PTTH)-stimulated immediate early gene that is, at least in part, induced through Ca(2+)/ERK and PI3K signaling. The present study proposes a potential cross talk mechanism between PTTH and ecdysone signaling to regulate insect development and lays a foundation for a better understanding of the mechanisms of PTTH's actions. PMID: 27090809
  2. There are interconnections among Ca(2+) signaling, adenosine 5'-monophosphate-activated protein kinase, and 4E-BP phosphorylation in in prothoracicotropic hormone (PTTH-activated prothoracic glands of Bombyx mori. PMID: 27751888
  3. Study reports the physical basis of neurohormone PTTH sensing by the receptor tyrosine kinase Torso. Hormone binding by Torso is asymmetric and anticooperative, allowing receptor levels to determine the nature of signal transduction. PMID: 26698662
  4. To examine the expression of Rab proteins and neuropeptide hormones in the brain of the silkworm, Bombyx mori.The Rab1 co-localized with prothoracicotropic hormone. PMID: 22922733
  5. PTTH/PI3K/TOR/4E-BP (S6K) signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands. PMID: 22227406
  6. The authors showed that Bombyx mori prothoracicotropic hormone (PTTH)-stimulated ecdysteroidogenesis was partially blocked by LY294002 and wortmannin, indicating that phosphoinositide 3-kinase (PI3K) is involved in PTTH-stimulated ecdysteroidogenesis. PMID: 21199670
  7. Study showed that prothoracicotropic hormone (PTTH) stimulates a rapid increase in tyrosine phosphorylation of at least 2 proteins in prothoracic glands: extracellular signal-regulated kinase and a 120-kDa protein. PMID: 20568296
  8. the TATA box is involved in regulation of PTTH gene expression in B. mori PMID: 20563654
  9. PTTH-stimulated ERK phosphorylation is only partially Ca(2+)- and calmodulin-dependent, and HNMPA-(AM)(3)-sensitive receptor tyrosine kinase is involved in activation of ERK phosphorylation by PTTH. PMID: 19800889

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Tissue Specificity
PTTH is synthesized by two dorsolateral neurosecretory cells of the Bombyx brain.
Database Links

KEGG: bmor:692767

UniGene: Bmo.125

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