RAB3D Antibody

1. targeting the Rab3D may be a potential therapeutic target for treatment of esophageal squamous cell carcinoma. PMID: 28472755
2. increased Rab3D expression is associated with invasiveness of CRC cells PMID: 27046094
3. High expression of small GTPase Rab3D promotes cancer progression and metastasis. PMID: 25823663
4. The presence of Rab3D(N135I) decreases the restriction of maturing secretory granules (SGs) to the F-actin-rich cell cortex, blocks the removal of the endoprotease furin from SGs and impedes the processing of the luminal SG protein secretogranin II. PMID: 23526941
5. Our findings indicate that Rab3D regulates the exocytosis of many components critical for the maintenance of oral physiology. PMID: 21702009
6. MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. PMID: 20038531
7. mutant Rab3D proteins interfere with the formation of bona fide Weibel-Palade bodies and consequently the acute, histamine-induced release of von-Willebrand factor PMID: 15257287

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HGNC: 9779

OMIM: 604350

KEGG: hsa:9545

STRING: 9606.ENSP00000222120

UniGene: Hs.744916